β-thujaplicin (CAS# 499-44-5)

Isakhiwo Samakhemikhali:

I-Molecular Formula	I-C10H12O2
I-Molar Mass	164.2
Ukuminyana	1.0041 (isilinganiso esinzima)
I-Melting Point	50-52°C(lit.)
I-Boling Point	140°C10mm Hg(lit.)
I-Flash Point	128.1°C
Ukuncibilika	Ayincibiliki emanzini
I-Vapor Presure	8.98E-05mmHg ku-25°C
Ukubukeka	Angenambala, amakristalu e-prismatic (aphinde acwebezeliswa kusukela ku-ethanol anhydrous)
Umbala	Emhlophe
I-Merck	14,9390
pKa	7.06±0.30(Kubikezelwe)
Isimo Sesitoreji	Kuvalwe endaweni eyomile, Ngezinga lokushisa Legumbi
Ukuzinza	Izinzile unyaka ongu-1 kusukela ngedethi yokuthenga njengoba kunikeziwe. Izixazululo ku-DMSO noma i-ethanol zingagcinwa ku -20° kuze kube yizinyanga ezi-4.
Kuyazwela	Gwema ukuthintana nama-oxide
I-Refractive Index	1.5190 (isilinganiso)
I-MDL	I-MFCD00059582
Isifundo se-in vitro	Kulayini weseli ye-glioma ye-U87MG kanye ne-T98G, i-hinokitiol ibonisa ukwehla okuncike kumthamo ekusebenzeni, ngamavelu e-IC 50 angu-316.5 ± 35.5 kanye no-152.5 ± 25.3 µM, ngokulandelanayo. I-Hinokitiol icindezela umsebenzi we-ALDH kanye nekhono lokuzivuselela kumaseli e-glioma stem, futhi ivimbela i-in vitro oncogenicity. I-Hinokitiol iphinde yehlise inkulumo ye-Nrf2 kumaseli e-glioma stem ngendlela encike kumthamo. I-Hinokitiol (0-100 μM) ivimbela ukukhula kwamangqamuzana omdlavuza wekoloni ngendlela encike kumthamo kanye nesikhathi. I-Hinokitiol (5, 10 μM) yehlisa i-DNMT1 ne-UHRF1 mRNA nesisho samaprotheni, futhi ikhuphula isisho se-TET1 ngokuthuthukiswa kwezinga le-5hmC kumaseli e-HCT-116. Ngaphezu kwalokho, i-hinokitiol yehlisa isimo se-methylation futhi ibuyisela inkulumo ye-mRNA ye-MGMT, CHST10, kanye nezakhi zofuzo ze-BTG4.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi	I-Xn - Iyingozi
Amakhodi Engozi	22 – Kuyingozi uma kugwinywe
Incazelo Yokuphepha	36 – Gqoka izingubo ezifanele zokuzivikela.
I-WGK Germany	3
I-RTECS	GU4200000

Isingeniso

I-Hinokiol, eyaziwa nangokuthi i-α-terpene alcohol noma i-Thujanol, iyinhlanganisela yemvelo yemvelo eyingxenye yezingxenye ze-turpentine. I-Hinoylol iwuketshezi olungenambala, olusobala olunephunga elimnandi likaphayini.

I-Hinokiol inezinhlobonhlobo zokusetshenziswa. Isetshenziswa kabanzi embonini yamakha kanye nephunga ukwengeza iphunga nephunga emikhiqizweni. Okwesibili, utshwala bomjunipha bubuye busetshenziswe njengesibulala-sikhunta kanye nesivimbeli, futhi kuvame ukusetshenziswa ekulungiseni izibulala-magciwane nezibulala-sikhunta.

Kunezindlela eziningana zokulungiselela i-juniperol. Ngokuvamile, ingakhishwa ngokukhipha amafutha ashisayo avela emaqabunga omjunipha noma ezinye izitshalo ze-cypress, bese ihlukaniswa futhi ihlanjululwe ukuze ithole ijuniperol. Utshwala be-Hinoki bungabuye buhlanganiswe nge-chemical synthesis.

Ulwazi lokuphepha lwe-juniperol: Ayinabuthi obuncane futhi ngokuvamile ibhekwa njengephephile. Njengenhlanganisela ye-organic, kusadingeka ukuthi iphathwe futhi igcinwe ngendlela efanele. Gwema ukuthinta isikhumba namehlo, futhi ugeze ngokushesha ngamanzi uma kwenzeka ukuthinta ngephutha. Kufanele igcinwe kude namalangabi avulekile kanye namazinga okushisa aphezulu, futhi igcinwe endaweni epholile, eyomile.

Okwedlule: Z-ASP-OBZL(CAS# 4779-31-1)

Olandelayo: 3-(Trifluoromethoxy)benzyl bromide (CAS# 50824-05-0)

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