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2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Isithombe Esifakiwe
  • 2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C5H4Cl2N2
I-Molar Mass 163
Ukuminyana 1.39 g/mL ku-25 °C (okhanyisiwe)
I-Melting Point 26-28 °C (okhanyisiwe)
I-Boling Point 108-109 °C/11 mmHg (okhanyisiwe)
I-Flash Point >230°F
Ukuncibilika Incibilika ku-chloroform, ether, ethyl acetate ne-toluene
I-Vapor Presure 0.079mmHg ku-25°C
Ukubukeka impushana ukuya egangeni ukuze usule uketshezi
Umbala Okumhlophe noma Okungenambala Kucishe kube mhlophe noma Kucishe kungabi mbala
pKa -2.44±0.29(Kubikezelwe)
Isimo Sesitoreji Umkhathi ongenayo, 2-8°C

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

Izimpawu Eziyingozi C – Iyabola
Amakhodi Engozi 34 - Ibangela ukusha
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu ​​kanye nokuvikela iso/ubuso.
S45 – Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
S27 – Khumula ngokushesha zonke izingubo ezingcolile.
Ama-ID e-UN UN 3261 8/PG 2
I-WGK Germany 3
I-TSCA Yebo
Ikhodi ye-HS 29335990
I-Hazard Class 8
Iqembu Lokupakisha III

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Ulwazi

Sebenzisa 2, 4-dichloro-5-methylpyrimidine ingasetshenziswa ekulungiseleleni i-2-fluoro-5-trifluoromethylpyrimidine. I-2-fluoro-5-trifluoromethylpyrimidine iyingxenye ebalulekile yokuhlanganiswa kwemithi, engasetshenziswa ukwenza ama-compounds e-dihydrofuran ehlanganisiwe, kanye nezinhlanganisela ze-dihydrofuran ezihlanganisiwe zingasetshenziswa njenge-G protein ehambisana ne-receptor GPR119 modulators, ekwelapheni isifo sikashukela, ukukhuluphala kanye nesifo se-dyslipidemia. Ngaphezu kwalokho, i-2-fluoro-5-trifluoromethylpyrimidine ingasetshenziswa futhi njengendawo ephakathi ekuhlanganiseni kwezidakamizwa zokwelashwa kwesifo se-Alzheimer kanye nesifo sengqondo.
ukulungiselela I-5-methyluracil 75g(0.59mol), i-phosphorus oxychloride 236g, i-triethylamine hydrochloride 16.5g(0.12mol), yengezwe kuflask yokusabela, ishisiswe ku-100 ℃ ~ 110 ℃, Reflux reaction 5H, cooled ℃ chloride ku-4 ℃ 248(1.19mol), ukusabela kokugcina ukushisa 2H. Ngemva kokuphothulwa kokusabela, i-phosphorus oxychloride yatholwa ngokufakwa emanzini ngaphansi kwengcindezi encishisiwe, futhi ukucwiliswa ngaphansi kwengcindezi encishisiwe kwaqhutshekwa nokuthola u-88g(0.54mol) we-2, 4-dichloro-5-methylpyrimidine ngesivuno esingu-91.5%.
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