2 4-Difluorobenzoic acid (CAS# 1583-58-0)

Isicelo

I-2, 4-difluorobenzoic acid iyisidakamizwa esibalulekile kanye nesibulala-zinambuzane esiphakathi, njenge-2, 4-difluorobenzoic acid ikakhulukazi esetshenziselwa ukuhlanganiswa kwezidakamizwa ze-antifungal fluconazole, i-voriconazole kanye nesibulala-zinambuzane esiphakathi kwe-4-fluorosalicylic acid, izidakamizwa eziphakathi 3, 5-difluoro, njll. 2, 4-difluorobenzoic acid can futhi isetshenziswe ezintweni ze-crystal eziwuketshezi, ezinezinzuzo zenani eliphakeme kanye namathemba amahle emakethe.

Ukulungiselela

Engeza u-2, 4-dinitrotoluene namanzi emkhunjini wokusabela, lungisa inani le-pH libe ngu-7, gqugquzela futhi ukushisa ku-75°C. I-Potassium permanganate, i-magnesium sulfate kanye ne-phase transfer catalyst yengezwe ngamaqoqo. Ngemuva kokungeza, qhubeka ugoqa futhi usabele ekushiseni okungashintshi amahora amathathu. Hlunga ngesikhathi kushisa bese ugeza ikhekhe lokuhlunga ngamanzi ashisayo. Hlanganisa i-filtrate, i-acidify ne-35% hydrochloric acid kuya ku-pH 2-3, kunenani elikhulu lemvula emhlophe ngemva kokuba amakristalu egcwele ngokuphelele, ahlungiwe, agezwe, afakwe kabusha, futhi omiswe ukuze uthole amakristalu amhlophe njenge-2,4-dinitrobenzoic acid. . Isilinganiso se-2, 4-dinitrotoluene ne-potassium permanganate singu-2.4:1. Isivuno somkhiqizo salesi sinyathelo singama-90.7%.

engeza i-N,N-dimethylmethylphthalamide esitsheni sokusabela, ukushisa ku-100~110 ℃, ukushisa kuqala okungu-0.5~1h. Engeza i-anhydrous potassium fluoride eyomile ngaphansi kokugqugquzela futhi ugcine izinga lokushisa lishisa ngaphambili kwe-0.5-1h. Ngemuva kwalokho, i-2, i-4-dinitrobenzoic acid ne-hexyltrimethylammonium bromide yengezwe ngokushesha emkhunjini wokusabela ngesikhathi esisodwa, futhi ukushisa kwaqhutshelwa ku-120 ℃, izinga lokushisa lagcinwa futhi ukusabela okushukumisayo kwaqhubeka. Ngemuva kwamahora angu-7 wokusabela kwe-reflux, i-solvent ibuyiselwa ngokuxutshwa, bese uketshezi olusabelayo luhlanjululwa ngesitimu. Ingxenye eqoqwe i-emulsion emhlophe. Ngemva kokuma isikhathi esithile, ingxenyenamba ehloselwe uwoyela ngokuyisisekelo ishona phansi, kuthelwe uketshezi olumhlophe olucacile engxenyeni engenhla, futhi uwoyela uyapholiswa ukuze kuncishiswe amakristalu amhlophe ukuze kutholwe umkhiqizo ongahluziwe; umkhiqizo ongahluziwe uyahlungwa kabusha, ukusefa, ukuwashwa, nokomiswa ukuze kutholwe amakristalu amhlophe e-2,4-difluorobenzoic acid. Isilinganiso senani le-2, 4-dinitrobenzoic acid ne-potassium fluoride ngu-2.7:1. Isivuno somkhiqizo salesi sinyathelo singama-72.4%.

Isingeniso
I-2,4-Difluorobenzoic acid iyinhlanganisela yezinto eziphilayo. Okulandelayo yisingeniso sezakhiwo, ukusetshenziswa, izindlela zokulungiselela kanye nolwazi lokuphepha lwe-2,4-difluorobenzoic acid:

Ikhwalithi:
- Ukubukeka: I-2,4-Difluorobenzoic acid iyi-crystalline solid solid.
- Ukunyibilika: Incibilika kuzincibilikisi ezivamile ezifana ne-ethanol, i-methanol ne-methylene chloride.

Sebenzisa:
- Izinto ezibonakalayo: Ingasetshenziswa futhi njengenye yezinto zokusetshenziswa zokulungiswa kwezinto ezibonakalayo namafilimu optical.
- Izicelo zezimboni: I-2,4-difluorobenzoic acid ingasetshenziswa embonini ye-electronics, imboni yezingubo zokugqoka kanye nepulasitiki ene-anti-corrosion, anti-oxidation kanye nemiphumela elwa ne-ultraviolet.

Indlela:
- I-2,4-Difluorobenzoic acid ingatholakala nge-fluorination ye-hydrofluoric acid nge-p-methylanisole.

Ulwazi Lokuphepha:
- Uma usebenza, uthuli kufanele lugwenywe ukuze ugweme ukuhogela futhi uthintane namehlo. Ngesikhathi esifanayo, izimo ezinhle zokungenisa umoya kufanele zigcinwe.
- Gwema ukuthintana nama-oxidizing aqinile noma ama-asidi aqinile ukuze ugweme ukusabela okuyingozi