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2-Amino-6-bromopyridine (CAS# 19798-81-3) Isithombe Esifakiwe
  • 2-Amino-6-bromopyridine (CAS# 19798-81-3) 1

2-Amino-6-bromopyridine (CAS# 19798-81-3)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C5H5BrN2
I-Molar Mass 173.01
Ukuminyana 1.710±0.06 g/cm3(Kubikezelwe)
I-Melting Point 88-91 °C (okhanyisiwe)
I-Boling Point 273.0±20.0 °C(Kubikezelwe)
I-Flash Point 118.9°C
Ukuncibilika kwamanzi Incibilika kancane emanzini.
Ukuncibilika I-Chloroform (Kancane), i-Methanol (Kancane Kancane)
I-Vapor Presure 0.0059mmHg ku-25°C
Ukubukeka Impushana emhlophe kuya kokunsundu
Umbala Iphuzi kancane ukuya kunsundu ngokukhanyayo
pKa 2.73±0.24(Okubikezelwe)
Isimo Sesitoreji Gcina endaweni emnyama, evalwe endaweni eyomile, Emazingeni Okushisa Egumbi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

Amakhodi Engozi R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R20/21/22 – Kuyingozi ngokuhogela umoya, ukuthintana nesikhumba futhi uma ukugwinyile.
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S36 – Gqoka izingubo ezifanele zokuzivikela.
S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu ​​kanye nokuvikela iso/ubuso.
I-WGK Germany 3
Ikhodi ye-HS 29333999
I-Hazard Class I-IRRITANT

 

 

2-Amino-6-bromopyridine (CAS# 19798-81-3) Ulwazi

Uhlolojikelele I-2-amino esikhundleni se-nitrogen equkethe i-heterocyclic compounds enamalungu ayisithupha inezinhlelo zokusebenza ezibalulekile embonini yamakhemikhali, njenge-2-amino -6-Bromopyridine ingenye yezakhiwo ezibalulekile emithini yokwenziwa kanye nama-molecule amakhemikhali ezolimo, futhi isetshenziswa kabanzi ekuhlanganiseni. yemikhiqizo yemvelo, izidakamizwa, izinto zokukhanya kanye namakhemikhali ahlukahlukene amahle.
Isicelo I-2-amino esikhundleni se-nitrogen equkethe izinhlanganisela ze-heterocyclic ezinamalungu ayisithupha zinezinhlelo zokusebenza ezibalulekile embonini yamakhemikhali, njenge-2-amino -6-Bromopyridine ingenye yezakhiwo ezibalulekile emithini yokwenziwa kanye nama-molecule amakhemikhali ezolimo, futhi isetshenziswa kabanzi ekuhlanganiseni yemikhiqizo yemvelo, izidakamizwa, izinto zokukhanya kanye namakhemikhali ahlukahlukene amahle.
Ukulungiselela Ukulungiswa kwe-2-amino-6-bromopyridine: Engeza i-2-fluoro-6-bromo-pyridine (1mmol), i-pentamidine hydrochloride (2mmol), i-sodium tert-butoxide (3mmol), HO(0.5mL) ne-diethylene glycol dimethyl ether (2.5) mL) kushubhu yokusabela engu-25 ml. Ukusabela kwenziwa ku-150 ℃ amahora angama-24. Ngemva kokuqedwa kokusabela, yapholiswa yaba izinga lokushisa elilingana negumbi. Faka u-10mL we-ethyl acetate ukuze ucime ukusabela, engeza u-6mL wamanzi anosawoti agcwele ukugeza, uhlukanise isigaba sezinto eziphilayo, bese ukhipha isigaba samanzi nge-ethyl acetate izikhathi ezingu-3 (umthamo we-ethyl acetate isikhathi ngasinye ngu-6mL) bese uhlanganisa i-organic. isigaba, engeza i-anhydrous sodium sulfate ukuze yome, susa i-solvent kuhlanganise ne-organic solvent kanye ne-inorganic solvent by vacuum i-distillation, bese uhlukanisa i-solvent ephilayo ngekholomu chromatography ukuze kutholwe umkhiqizo ohlosiwe ongu-2-amino-6-bromopyridine onesivuno esingu-93%.
sebenzisa abalamuli bemithi.
ukuze kuhlanganiswe kahle i-7-azafindole embizeni eyodwa; ukuze kuhlanganiswe imishanguzo elwa ne-HIV

 

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