2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine(CAS#865363-93-5)
Sethula i-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), i-groundbreaking nucleoside analog ehlelelwe ukuguqula umkhakha we-molecular biology kanye nocwaningo lwezemithi. Le nhlanganisela emisha iklanyelwe ukuthuthukisa ukuqonda ukusebenzisana kwe-nucleic acid nezinqubo zamaselula, okuyenza ibe ithuluzi eliyigugu kubacwaningi nakososayensi ngokufanayo.
I-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine ibonakala ngokuguqulwa kwayo kwesakhiwo okuyingqayizivele, okuhlanganisa ukushintshwa kwe-ethynyl ne-fluorine endaweni engu-4′ no-2′, ngokulandelana. Lezi zinguquko azithuthukisi nje kuphela ukuzinza kanye nokuba khona kwe-bioavailability kwenhlanganisela kodwa futhi zithuthukisa amandla ayo okungena kulwelwesi lwamangqamuzana, okuvumela ukulethwa okuphumelelayo nokutholwa ezinhlelweni ezihlukahlukene zebhayoloji.
Le analogi ye-nucleoside ibonise amandla athembisayo ezinhlelweni ezihlukahlukene, okuhlanganisa ucwaningo lwe-antiviral kanye nomdlavuza. Ikhono layo lokulingisa ama-nucleosides emvelo ngenkathi libonisa izici ezihlukile ze-biochemical liyenza ibe yikhandidethi efanelekile yokuthuthukiswa kwama-ejenti amasha okwelapha. Abacwaningi bangasebenzisa i-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine ukuze bafunde i-RNA ne-DNA synthesis, baphenye ukusebenzisana kwama-enzyme, futhi bahlole izindlela zokusebenza zemithi ekhona.
Ngaphezu kwezicelo zayo zocwaningo, lesi sithako siphinde silungele ukudlala indima ebalulekile ekuthuthukisweni kwezindlela zokwelapha zesizukulwane esilandelayo. Ngokunikeza imininingwane ngokuziphatha kwe-nucleic acid nokusebenzisana, i-2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine ingasiza ekwakhiweni kokwelashwa okuphumelelayo nokuhlosiwe kwezifo ezihlukahlukene.
Kafushane, i-2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) iyi-analog ye-nucleoside esezingeni eliphezulu enikeza amathuba angenakuqhathaniswa okucwaninga nokuthuthukiswa kubhayoloji yamangqamuzana nesayensi yezokwelapha. Yamukela ikusasa lokutholwa kwesayensi ngale nhlanganisela eyingqayizivele futhi uvule amathuba amasha emizamweni yakho yocwaningo.
