2,4,5-Trifluorophenylacetic Acid (CAS# 209995-38-0)
Isicelo
I-2,4, 5-trifluorophenylacetic acid iqinile emhlophe esetshenziselwa ukuhlanganiswa kwezidakamizwa ezintsha ze-sitagliptin ekwelapheni isifo sikashukela sohlobo II. I-sitagliptin iyi-DPP-IV inhibitor yokuqala esanda kufakwa ohlwini ngabakwa-Merck. Inomphumela omuhle wokwelapha, imiphumela emibi emincane, ukuphepha okuhle nokubekezelelana ekwelapheni uhlobo lwesifo sikashukela sohlobo II, futhi inamathemba abanzi emakethe.
Ukucaciswa
Ukubukeka Crystallization
Faka umbala omhlophe ukuya kokumhlophe
pKa 3.78±0.10(Kubikezelwe)
Isimo Sesitoreji Sivalwe ngokomile, Izinga lokushisa Legumbi
I-Refractive Index 1.488
Ukuphepha
Izimpawu Zengozi Xi - Iyacasula
Iyacasula
Amakhodi Engozi R37/38 - Ukucasula uhlelo lokuphefumula kanye nesikhumba.
R41 - Ingozi yokulimala okubi emehlweni
Incazelo Yezokuphepha S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S39 - Gqoka ukuvikela iso / ubuso.
I-WGK Germany 3
I-HS Code 29163990
I-Hazard Class IRRITANT
Ukupakisha Nokugcina
Ipakishwe ezigubhu ezingu-25kg/50kg. Gcina endaweni emnyama, evalwe endaweni eyomile, Emazingeni Okushisa Egumbi
Isingeniso
Kwethulwa i-2,4,5-Trifluorophenylacetic Acid, okuqinile okumhlophe okusetshenziswa kakhulu embonini yezemithi ukuze kuhlanganiswe i-sitagliptin intermediate yokwelapha uhlobo lwesifo sikashukela sohlobo II.
Njengengxenye ebalulekile ekukhiqizweni kwe-sitagliptin, i-2,4,5-Trifluorophenylacetic Acid ibambe iqhaza elibalulekile ekwakhiweni kwalo muthi osebenza kahle kakhulu. I-Sitagliptin iyi-inhibitor yakamuva ye-DPP-IV esanda kufakwa ohlwini ngabakwa-Merck. Inemiphumela emihle kakhulu yokwelapha, imiphumela engemihle emincane, ukuphepha nokubekezelelana, futhi isiphenduke umuthi osetshenziswa ekwelapheni uhlobo lwesifo sikashukela sohlobo II.
Enye yezinzuzo ezibalulekile ze-2,4,5-Trifluorophenylacetic Acid ukuthi yenza ukukhiqizwa kwe-sitagliptin ngezindleko eziphansi, okuvumela abantu abaningi ukuba bathole lo muthi oshintsha impilo. Ngaphezu kwalokho, iphumelela kakhulu ekwelapheni isifo sikashukela futhi inikeza ithemba elisha kulabo abanenkinga yalesi simo.
Ukubukeka kwe-2,4,5-Trifluorophenylacetic Acid iyimpushana emhlophe qwa ukuya kokumhlophe, okwenza kube lula ukuyibona, ukuyiphatha, kanye nokuthutha. Iphinde izinze ngaphansi kwezimo ezijwayelekile, okusho ukuthi ingagcinwa isikhathi eside ngaphandle kokwehlisa isithunzi.
I-2,4,5-Trifluorophenylacetic Acid iguquguquka kakhulu futhi ingasetshenziswa ekuhlanganiseni ezinye izinhlanganisela eziyinkimbinkimbi ngale kwe-sitagliptin intermediates. Inezinhlelo zokusebenza ezihlukene zezimboni, okuhlanganisa ukukhiqizwa kwamakhemikhali e-agrochemicals, ama-resin, kanye ne-intermediates. Ingasetshenziswa futhi njengesiqalo sokuhlanganiswa kohlu olubanzi lwama-molecule anezinhlelo zokusebenza ezahlukene.
Enkampanini yethu, siyaziqhenya ngokuhlinzeka ngekhwalithi ephezulu ye-2,4,5-Trifluorophenylacetic Acid kumakhasimende ethu. Umkhiqizo wethu uhlangabezana nezindinganiso zekhwalithi ephezulu futhi ukhiqizwa ngokulandela imihlahlandlela eqinile ukuze kuqinisekiswe ukuvumelana nobumsulwa.
Sengiphetha, i-2,4,5-Trifluorophenylacetic Acid iyinhlanganisela ewusizo kakhulu eye yaba ingxenye ebalulekile ekukhiqizweni kwe-sitagliptin, umuthi womugqa wokuqala wesifo sikashukela sohlobo lwesibili. Ukuguquguquka kwayo nokusebenza ngempumelelo kwayo kuyenza ibe yimpahla ebalulekile ezimbonini zemithi namakhemikhali, futhi siyaziqhenya ngokunikeza amakhasimende ethu i-Acid yekhwalithi ephezulu engu-2,4,5-Trifluorophenylacetic.
