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I-4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4) Isithombe Esifakiwe
  • I-4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4) 1

I-4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C7H4BrFO2
I-Molar Mass 219.01
Ukuminyana 1.789±0.06 g/cm3(Kubikezelwe)
I-Melting Point 207 °C
I-Boling Point 296.1±25.0 °C(Kubikezelwe)
I-Flash Point 132.9°C
I-Vapor Presure 0.000663mmHg ku-25°C
pKa 3.63±0.10(Okubikezelwe)
Isimo Sesitoreji Kuvalwe endaweni eyomile, Ngezinga lokushisa Legumbi

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Ulwazi Lwereferensi

Isebenzisa I-4-bromo-3-fluorobenzoic acid iyi-chemical material eluhlaza engasetshenziswa ukulungisa izinhlobo zezidakamizwa (njenge-benzamit anti-cancer drug).
Indlela yokuhlanganisa I-4-bromo-3-fluorobenzoic acid ingatholwa nge-oxidation ye-4-bromo-3-fluorotoluene nge-potassium permanganate.
(1) i-oxidation: 100kg we-kg4-bromo -3-fluorotoluene, 120kg wamanzi kanye no-0.1kg we-fatty alcohol polyether sodium sulfate (AES) kwengezwa ngokulandelana kugedlela lokusabela eline-glass-lined ye-K-400L (ekhiqizwe i-Jiangsu industrial lining chemical Equipment co., ltd.) ngomshini wokunyakazisa nokufudumeza kanye ne-condensation reflux, bese I-167kg ye-potassium permanganate yengezwa kancane kancane ngaphansi kwesimo esinyakazayo, igcinwe esimweni esibilayo, futhi iphendule amahora angu-9, imise ukusabela ngemva kokuba isisombululo se-reflux singasenabo ubuhlalu bamafutha;
(2) Ukuhlunga: hlunga isisombululo sokusabela esitholakala esinyathelweni (1) ngenkathi kushisa ukuze uthole isihlungi esiqukethe umkhiqizo ohlosiwe ongu-4-bromo -3-fluorobenzoic acid;
(3) Khipha i-potassium permanganate: Ukuze kukhishwe i-potassium permanganate esele ku-filtrate, u-0.1kg we-sodium sulfite kufanele wengezwe ku-filtrate etholakala esinyathelweni (2), inani elingeziwe le-sodium sulfite lisekelwe oketshezini olusobala no umbala onsomi wekhambi.
(4) ukufakwa kwe-acidification: esimweni sokunyakazisa, engeza kancane kancane into exazululweni etholakala esinyathelweni (3) nge-concentrate ye-12mol/L ye-hydrochloric acid. lapho inani le-pH lesisombululo lingu-2.2, yeka ukungeza i-hydrochloric acid egxilile futhi uqhubeke nokusabela kwe-30min.
5 Ngesikhathi sokusebenza, kufanele ishukunyiswe ngokuqhubekayo, ngaphandle kwalokho i-4-bromo-3-fluorobenzoic acid izokwakha ukuqina okukhulu, okunzima ukubhekana nayo ezinkambisweni ezilandelayo;
(6) Ukuhlunga nokuwashwa: Uketshezi oluxubile oluqukethe amakristalu angu-4-bromo-3-fluorobenzoic acid atholakala esinyathelweni (5) lufakwa phakathi ukuze kutholwe ikhekhe lokuhlunga elingumkhiqizo ongahluziwe we-4-bromo-3-fluorobenzoic acid, umkhiqizo ongahluziwe. igezwa ngamanzi ahlanzekile futhi ifakwe i-centrifuge (kusetshenziswa i-centrifuge enomshini wokuwasha) ukuze ithole ukucolisiswa 4-bromo-3-fluorobenzoic acid;
(7) Ukomisa: I-4-bromo-3-fluorobenzoic acid eqinile elungiselelwe isinyathelo (6) yomiswa ku-75°C amahora angu-12 ukuze kutholwe i-197 kg4-bromo-3-fluorobenzoic acid, okuqukethwe kwayo kungaphezu kuka-98 %.
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