5-Bromo-2-fluoro-4-methyl-pyridine (CAS# 864830-16-0)
| Amakhodi Engozi | I-R22 – Iyingozi uma igwinywe R37/38 – Ukucasula uhlelo lokuphefumula kanye nesikhumba. R41 – Ingozi yokulimala okubi emehlweni |
| Incazelo Yokuphepha | S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha. S39 – Gqoka ukuvikela iso / ubuso. |
| I-Hazard Class | I-IRRITANT |
Isingeniso
Kuyinhlanganisela ye-organic enefomula ye-molecular C≡H∞BrFN, ene-athomu ye-fluorine, iqembu le-methyl kanye ne-athomu ye-bromine esikhundleni sendandatho ye-pyridine.
Imvelo:
iqinile, inobuthi futhi iyacasula. Iyancibilika kuzincibilikisi zemvelo njenge-ethanol ne-dimethylformamide ekamelweni lokushisa, futhi ingaba ibhondi ye-hydrogen nabanye abamukela ibhondi ye-hydrogen (isb, utshwala).
Sebenzisa:
Ivame ukusetshenziswa njengento yokuqala noma ephakathi kokusabela kwe-organic synthesis. Ingasetshenziswa ekulungiseleleni imithi, izibulala-zinambuzane kanye nezinye izinhlanganisela eziphilayo. Uhlu olubanzi lwezicelo lwayo lubandakanya ucwaningo lwezemithi, ukuhlanganiswa kwamakhemikhali nesayensi yezinto.
Indlela Yokulungiselela:
Indlela yokulungiselela i-fluorination ingafinyelelwa nge-benzyl bromination kanye ne-fluorination. Okokuqala, i-benzyl compound (4-methylpyridine) isabela nge-benzylidene bromide ukukhiqiza i-bromobenzyl compound (2-bromo-4-methylpyridine). Lesi sithako sibe sesisabela nge-hydrofluoric acid ukukhiqiza umkhiqizo ohambisana ne-fluorinated (phosphonium).
Ulwazi Lokuphepha:
inobuthi, kufanele ithathe izinyathelo zokuzivikela ezifanele. Gwema ukuthinta isikhumba, amehlo kanye nomgudu wokuphefumula ngesikhathi sokusebenza. Kufanele isetshenziswe endaweni enomoya omuhle, futhi gqoka izibuko zokuzivikela ezifanele, amagilavu namamaski. Zigcine kude nomlilo nama-oxidizing agents, futhi ugweme ukusabela kwamanye amakhemikhali. Uma uveziwe noma uhogelwe, funa iseluleko sezokwelapha ngokushesha.
