5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)
Ubungozi Nokuphepha
| Amakhodi Engozi | I-R22 – Iyingozi uma igwinywe R37/38 – Ukucasula uhlelo lokuphefumula kanye nesikhumba. R41 – Ingozi yokulimala okubi emehlweni R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba. R20 – Kuyingozi ngokuhogela umoya |
| Incazelo Yokuphepha | S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha. S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu kanye nokuvikela iso/ubuso. S36 – Gqoka izingubo ezifanele zokuzivikela. |
| Ama-ID e-UN | 2811 |
| I-WGK Germany | 3 |
| Ikhodi ye-HS | 29337900 |
| Inothi Lengozi | Kuyingozi |
| I-Hazard Class | I-IRRITANT |
Ulwazi Lwereferensi
| Sebenzisa | I-5-bromo-2-hydroxy-3-nitropyridine i-organic intermediate engasetshenziswa ukulungisa izinhlanganisela 3-amino-1-(2-oxo-2-(3 '-(trifluoromethyl)-[1,1'-biphenyl ]-4-yl) i-ethyl)-5-(pyrrole i-alkyl-1-yl-sulfonyl) pyridin-2 (1H)-one, le nhlanganisela iyinhlanganisela ye-DOCK1 evimbelayo. |
| indlela yokuhlanganisa | i-nitric acid (60-61%,3.5mL) yengezwe kusixazululo (10mL) se-5-bromopyridine -2(1H)-one (1.75g,10.1mmol) ku-sulfuric acid ku-0 ℃. Ingxube ivunyelwe ukushiswa ekamelweni lokushisa futhi igxilwe amahora angu-3. Ingxube yokusabela ithululelwa emanzini eqhwa futhi imvula ewumphumela iqoqwa ngokuhlunga. Umkhiqizo owenziwe wagezwa ngamanzi futhi womiswa ku-vacuum, unikeza i-5-bromo-2-hydroxy-3-nitropyridine (isivuno esingu-960mg,43%) njengesiqinile esimhlophe. 1H I-NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
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