5-Fluorocytosine (CAS# 2022-85-7)
Ubungozi Nokuphepha
| Amakhodi Engozi | R40 – Ubufakazi obuncane bomphumela we-carcinogenic R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba. R63 – Ingozi engaba khona yokulimala enganeni engakazalwa |
| Incazelo Yokuphepha | S22 - Ungaphefumuli uthuli. I-S24/25 - Gwema ukuthintana nesikhumba namehlo. S45 – Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.) I-S36/37 – Gqoka izingubo zokuzivikela ezifanele namagilavu. S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu kanye nokuvikela iso/ubuso. S27 – Khumula ngokushesha zonke izingubo ezingcolile. S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha. |
| I-WGK Germany | 2 |
| I-RTECS | I-HA6040000 |
| AMAKHODI E-FLUKA BRAND F | 10-23 |
| Ikhodi ye-HS | 29335990 |
| Inothi Lengozi | Inobuthi/Izwela Ukukhanya |
| I-Hazard Class | I-IRRITANT, LIGHT IYABONA |
| Ubuthi | I-LD50 kumagundane (mg/kg): >2000 ngomlomo kanye ne-sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Isingeniso
izinga
Lo mkhiqizo uyimpushana yekristalu emhlophe noma emhlophe, ayinaphunga noma iphunga kancane. Incibilika kancane emanzini, ukunyibilika okungu-1.2% ku-20 °C emanzini, kuncibilika kancane ku-ethanol; Cishe ayincibiliki ku-chloroform ne-ether; Incibilika ku-dilute hydrochloric acid noma i-dilute sodium hydroxide solution. Iyazinza ekamelweni lokushisa, imvula amakristalu lapho kubanda, futhi ingxenye encane iguqulwa ibe ngu-5-fluorouracil uma ishisiwe.
Lo mkhiqizo uyisidakamizwa esilwa nesikhunta esakhiwe ngo-1957 futhi sasetshenziswa emtholampilo ngo-1969, esinomphumela osobala we-antibacterial ku-Candida, i-cryptococcus, isikhunta esinemibala ne-Aspergillus, futhi awukho umphumela ovimbelayo kwezinye isikhunta.
Umphumela wayo ovimbelayo kusikhunta ungenxa yokungena kwawo kumaseli esikhunta esibucayi, lapho ngaphansi kwesenzo se-nucleopyine deaminase, kususa amaqembu ama-amino ukuze akhe i-antimetabolite-5-fluorouracil. Lesi sakamuva siguqulwa sibe yi-5-fluorouracil deoxynucleoside futhi ivimbele i-thymine nucleoside synthetase, ivimbele ukuguqulwa kwe-uracil deoxynucleoside ibe yi-thymine nucleoside, futhi ithinte ukuhlanganiswa kwe-DNA.
sebenzisa
Ama-Antifungal. Isetshenziselwa ikakhulukazi i-mucocutaneous candidiasis, i-candidal endocarditis, i-candidal arthritis, i-cryptococcal meningitis kanye ne-chromomycosis.
Ukusetshenziswa kanye nomthamo Oral, 4 ~ 6g ngosuku, ihlukaniswe izikhathi 4.
ezokuphepha
Izibalo zegazi kufanele zihlolwe njalo ngesikhathi sokuphatha. Iziguli ezinesifo sesibindi nezinso kanye nezifo zegazi kanye nabesifazane abakhulelwe kufanele basebenzise ngokuqapha; I-contraindicated ezigulini ezinokwehluleka okukhulu kwezinso.
I-shading, isitoreji esingangenisi umoya.
