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5-Fluorouracil (CAS# 51-21-8) Isithombe Esifakiwe
  • 5-Fluorouracil (CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C4H3FN2O2
I-Molar Mass 130.08
Ukuminyana 1.4593 (isilinganiso)
I-Melting Point 282-286 °C (dec.) (lit.)
I-Boling Point 190-200°C/0.1mmHg
Ukuncibilika kwamanzi 12.2 g/L 20 ºC
Ukuncibilika Incibilika kancane ku-ethanol. Cishe ayincibiliki ku-chloroform futhi incibilike kusixazululo se-sodium hydroxide.
Ukubukeka I-crystalline powder emhlophe noma emhlophe
Umbala mhlophe
I-Merck 14,4181
I-BRN 127172
pKa pKa 8.0±0.1 (H2O) (Akuqinisekile);3.0±0.1(H2O) (Akuqinisekile)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Isimo Sesitoreji 2-8°C
Ukuzinza Izinzile. Ukuzwela ukukhanya. Okuvuthayo. Akuhambisani nama-oxidizing agents aqinile, izisekelo eziqinile.
Kuyazwela Kuyazwela emoyeni
I-Refractive Index 1.542
I-MDL I-MFCD00006018
Izakhiwo Zomzimba Nezamakhemikhali iphoyinti elincibilikayo 282-286°C (dec.)(lit.)izimo zesitoreji Gcina ku-0-5
ukunyibilika kwe-H2O: 10 mg/mL, kucacile

ifomu powder

umbala omhlophe

ukuncibilika kwamanzi 12.2g/L 20 oC
Umoya Ozwelayo
merck 14,4181
I-BRN 127172
Sebenzisa Ngomdlavuza wesistimu yokugaya ukudla, umdlavuza wekhanda nentamo, umdlavuza wabesifazane, umdlavuza wamaphaphu, umdlavuza wesibindi, umdlavuza wesinye kanye nokwelashwa komdlavuza wesikhumba.

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Amakhodi Engozi I-R22 – Iyingozi uma igwinywe
R20/21/22 – Kuyingozi ngokuhogela umoya, ukuthintana nesikhumba futhi uma ukugwinyile.
R52 – Iyingozi ezintweni eziphila emanzini
R25 – Kunobuthi uma ugwinywe
Incazelo Yokuphepha S36 – Gqoka izingubo ezifanele zokuzivikela.
I-S36/37 – Gqoka izingubo zokuzivikela ezifanele namagilavu.
S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu ​​kanye nokuvikela iso/ubuso.
S22 - Ungaphefumuli uthuli.
S45 – Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
Ama-ID e-UN UN 2811 6.1/PG 3
I-WGK Germany 3
I-RTECS YR0350000
AMAKHODI E-FLUKA BRAND F 10-23
I-TSCA T
Ikhodi ye-HS 29335995
Inothi Lengozi Iyacasula/Inobuthi Kakhulu
I-Hazard Class 6.1
Iqembu Lokupakisha III
Ubuthi I-LD50 ngomlomo kuNogwaja: 230 mg/kg

 

Isingeniso

Lo mkhiqizo uqala ukuguqulwa ube yi-5-fluoro-2-deoxyuracil nucleotides emzimbeni, evimbela i-thymine nucleotide synthase futhi ivimbele ukuguqulwa kwe-deoxyuracil nucleotide ibe yi-deoxythymine nucleotides, ngaleyo ndlela ivimbele i-DNA biosynthesis. Ngaphezu kwalokho, ngokuvimbela ukufakwa kwe-uracil ne-rotic acid ku-RNA, umphumela wokuvimbela ukuhlanganiswa kwe-RNA kufinyelelwa. Lo mkhiqizo umuthi othize womjikelezo wamaseli, ikakhulukazi ovimbela amaseli esigaba sika-S.

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