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alpha-Arbutin (CAS# 84380-01-8) Isithombe Esifakiwe
  • alpha-Arbutin (CAS# 84380-01-8) 1

alpha-Arbutin (CAS# 84380-01-8)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C12H16O7
I-Molar Mass 272.25
Ukuminyana 1.556±0.06 g/cm3(Kubikezelwe)
I-Melting Point 195-196°C
I-Boling Point 561.6±50.0 °C(Kubikezelwe)
I-Flash Point 293.4°C
Ukuncibilika I-Soluble ku-methanol, i-ethanol, i-DMSO nezinye izincibilikisi eziphilayo
I-Vapor Presure 1.9E-13mmHg ku-25°C
Ukubukeka I-crystalline powder emhlophe
Umbala Okumhlophe kuya kokumhlophe
I-BRN 89675
pKa 10.10±0.15(Okubikezelwe)
Isimo Sesitoreji 2-8°C
I-Refractive Index 1.65
I-MDL I-MFCD09838262
Izakhiwo Zomzimba Nezamakhemikhali Iphoyinti lokuncibilika 195-196°C

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

I-WGK Germany 3

 

Ulwazi

Uhlolojikelele I-arbutin iyinhlanganisela ye-hydroquinone glycoside, igama lekhemikhali le-4-hydroxyphenyl-d-glucopyranoside (y), ikhona kusithelo sebhere, i-bilberry nezinye izitshalo, iyizinto ezintsha ezingacasuli, ezingagulisi, ezisebenza zibe mhlophe zemvelo ezinokuhambisana okuqinile. I-Arbutin inamaqembu amabili asebenzayo esakhiwo nokusebenzayo esakhiweni sayo samangqamuzana: eyodwa iyinsalela ye-glucose; Elinye iqembu le-phenolic hydroxyl. Isimo somzimba se-α-arbutin sibonakala siyimpushana emhlophe kuya kokukhanyayo, encibilika kakhulu emanzini ne-ethanol.
ukusebenza kahle I-α-arbutin inomphumela ongcono wokwelapha ezibazini ezibangelwa ama-UV Burns, inomphumela ongcono wokulwa nokuvuvukala, wokukhanda kanye nokuba mhlophe. Ingakwazi ukuvimbela ukukhiqizwa kanye nokufakwa kwe-melanin, isuse amabala nama-freckles.
indlela yokwenza Indlela yokwenza mhlophe ye-α-arbutin ivimbela ngokuqondile umsebenzi we-tyrosinase, ngaleyo ndlela yehlise ukukhiqizwa kwe-melanin, kunokunciphisa ukukhiqizwa kwe-melanin ngokuvimbela ukukhula kweseli noma ukubonakaliswa kofuzo lwe-tyrosinase. Njengoba i-α-Arbutin iyisithako esisebenzayo esisebenza kahle futhi esiphephe kakhudlwana esenza sibe mhlophe, izinkampani eziningi zezimonyo ekhaya naphesheya zithathe i-α-arbutin esikhundleni se-β-arbutin njengesithako esimhlophe.
Isicelo I-alpha-Arbutin iyikhemikhali efana ne-arbutin, ingavimbela ukukhiqizwa kanye nokufakwa kwe-melanin, isuse amabala namabala. Imiphumela ibonisa ukuthi i-arbutin ingavimbela umsebenzi we-tyrosinase ekugxilweni okuphansi kakhulu, futhi umphumela wayo ovimbelayo ku-tyrosinase ungcono kunalowo we-arbutin. I-alpha-arbutin ingasetshenziswa njenge-ejenti emhlophe kuzimonyo.
ukuhlanzwa kanye nokuhlonza isampula etholwe ukusabela yaqala yakhishwa nge-ethyl acetate, yabe ikhishwa nge-n-butanol, amasampuli aqoqwa ngokuhwamuka ku-evaporator ejikelezayo futhi afakwa i-centrifuged. I-supernatant yahlaziywa yi-HPLC futhi yaqhathaniswa ne-HPLC chromatogram ye-α-arbutin, ukuthi ingabe isampula kanye ne-α-arbutin zinesikhathi esifanayo sokugcina uma kuqhathaniswa, nokuthi ingabe isampuli iqukethe i-α-Arbutin kuchazwe ngaphambilini.

Umkhiqizo ngemva kokukhipha nokuhlanzwa uhlonzwe ngemodi ye-ion enhle ye-LC-ESI-MS/MS. Ngokuqhathanisa i-molecular mass ye-α-bear fruit nesisindo se-molecular mass of α-arbutin standard, kunganqunywa ukuthi ingabe umkhiqizo uyi-α-arbutin.
Ukusetshenziswa I-α-arbutin ingavimbela umsebenzi we-tyrosinase ekugxilweni okuphansi kakhulu, umphumela wayo ovimbelayo ku-tyrosinase ungcono kunalowo we-arbutin.
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