I-ALPHA-ISO-METHYLIONONE(CAS#127-51-5)
| Izimpawu Eziyingozi | Xi - Irritant |
| Amakhodi Engozi | 43 - Kungabangela ukuzwela ngokuthinta isikhumba |
| Incazelo Yokuphepha | I-S24/25 - Gwema ukuthintana nesikhumba namehlo. I-S36/37 – Gqoka izingubo zokuzivikela ezifanele namagilavu. |
| Ama-ID e-UN | I-UN1230 - iklasi 3 - PG 2 - Methanol, isisombululo |
| I-WGK Germany | 2 |
| Ubuthi | I-GRAS(FEMA). |
Isingeniso
ethula
Ingxube ye-methyl ne-ethyl isomethyl violet ketone kanye ne-methyl ne-ethyl ortho methyl violet ketone.
imvelo
I-Alpha isomethylprednisolone iyinhlanganisela yezinto eziphilayo. Iqinile ngekristalu ensomi. Emazingeni okushisa asekamelweni, inephunga elimnandi eliyingqayizivele.
I-Alpha isomethylprednisolone iyi-ketone enamakha. Itholakala ekuphenduleni kwe-methylation ye-violet alcohol futhi ibizwa ngokuthi isomethyl violet ketone. Isakhiwo sayo samangqamuzana siqukethe indandatho enamakha kanye neqembu le-ketone.
Ezingeni lokushisa lasekamelweni, liqinile, kodwa lingancibilika ngokufudumeza. Ayincibiliki emanzini, kodwa ingancibilika kwezinye izincibilikisi eziphilayo njenge-ethanol ne-dichloromethane. Iyazwela ekukhanyeni futhi ingabhekana nokusabela kwe-photolysis ngaphansi kwemisebe ye-ultraviolet.
Ngokuphathelene nezakhiwo zamakhemikhali, i-α - isomethylprednisolone iyinhlanganisela esebenzayo. Ingabhekana nokusabela okufana ne-oxidation, ukunciphisa, ukuhlanganisa, nokufaka esikhundleni. Ihlangana namanye ama-electrophilic reagents ukwenza imikhiqizo yokwengeza. Kungenziwa i-protonated phambi kwama-acids aqinile. Ingabuye iguqulwe ibe yi-ketone acid ngokusabela kwe-oxidation.
Indlela yokukhiqiza
Okulandelayo kuyindlela evamile yokukhiqiza i-alpha isomethylprednisolone:
Ukulungiswa kwezinto zokuqala: Lungiselela izinto zokuqala, kufaka phakathi i-Isobutyl ketone ne-Cyclohexanone. Lezi zinhlanganisela ezimbili ziyizandulela ezibalulekile zokwenziwa kwe-α - isomethylprednisolone.
Ukulungiselelwa kwesimo sokusabela: Thatha i-isodecanone ne-cyclohexanol ngaphansi kwezimo ezifanele. Isimo sokusabela esivamile ukuqhuba ukusabela ngaphansi kwezimo ze-acidic, futhi ama-acid catalysts asetshenziswa ngokuvamile ahlanganisa i-sulfuric acid (H2SO4) ne-phosphoric acid (H3PO4).
Izinyathelo zokusabela: Hlanganisa inani elithile le-isodecanone ne-cyclohexanol, bese wengeza i-acid catalyst. Khona-ke, ukusabela kwenziwa ezingeni lokushisa elifanele, nebanga lokushisa elivame ukusetshenziswa lika-50-70 degrees Celsius. Isikhathi sokusabela ngokuvamile singamahora ambalwa kuya emashumini wamahora.
Ukuhlukaniswa nokuhlanzwa: Ngemva kokuba ukusabela kuqediwe, umkhiqizo uhlanzwa engxubeni yokusabela nge-distillation noma ezinye izindlela zokuhlukanisa.
I-Crystallization kanye nokomisa: Gcoba bese womisa umkhiqizo ohlanzekile ukuze uthole umkhiqizo wokugcina we-alpha isomethylprednisolone.
