I-BOC-GLY-GLY-GLY-OH (CAS# 28320-73-2)

Isingeniso

I-Tert-Butoxycarbonylglycyl glycylglycine (i-Boc-Gly-Gly-Gly-OH) iyinhlanganisela yemvelo enezici ezilandelayo:

Imvelo:

-Ukubukeka: ngokuvamile i-crystal emhlophe noma i-crystalline powder

-Ifomula ye-molecular: C17H30N4O7

Isisindo samangqamuzana: 402.44g/mol

-Indawo yokuncibilika: mayelana ne-130-132 ° C

-I-Solubility: I-Soluble in organic solvents njenge-dimethylformamide (DMF), i-dichloromethane, i-chloroform, njll., engancibiliki emanzini.

Sebenzisa:

I-Boc-Gly-Gly-Gly-OH ivamise ukusetshenziswa ku-organic synthesis, ikakhulukazi njengamaqembu noma amaqembu avikelayo. Ingasetshenziswa njengeqembu elivikelayo lama-amino acids ukuvimbela ukusabela okungaqondile, futhi ivame ukusetshenziswa ekuhlanganiseni kwesigaba esiqinile, i-peptide synthesis kanye nokuhlanganiswa kwezidakamizwa.

Indlela:

Indlela evamile yokulungiselela i-Boc-Gly-Gly-Gly-OH ukwethula iqembu elivikelayo le-tert-butoxycarbonyl eqenjini le-carboxyl le-glycine. Izinyathelo ezithile zifaka:

1. I-Glycine isabela ngengxube ye-sodium nitrite ne-sulfuric acid ukuze ithole i-tert-butoxycarbonyl glycinate.

2. Iqembu lokuvikela i-Ester lisuswa ukusabela kwe-hydrolysis ukuthola i-Boc-glycine.

3. Phinda izinyathelo ezingenhla kabili ukuze wethule iqembu le-carboxyl le-glycine emaqenjini amabili okuvikela e-tert-butoxycarbonyl ngokulandelanayo ukuze uthole i-Boc-Gly-Gly-Gly-OH.

Ulwazi Lokuphepha:

Ukusetshenziswa kwe-Boc-Gly-Gly-Gly-OH kufanele kunake lezi zindaba zokuphepha ezilandelayo:

-Gwema ukuthinta isikhumba namehlo, njengoba kungase kucasule isikhumba namehlo.

-Gqoka amagilavu ​​okuzivikela afanele, izibuko nezingubo zokuzivikela ngesikhathi sokusebenza.

-Isebenza endaweni engenawo umoya ukuze ugweme ukuhogela uthuli noma umhwamuko wayo.

-kufanele igcinwe kude nomlilo, ukushisa kanye ne-oxidant, gcina isitsha sivaliwe, sigcinwe endaweni epholile, eyomile.