I-Boc-L-Glutamic acid 1-benzyl ester (CAS# 30924-93-7)

Isingeniso

I-Boc-L-Glutamic acid 1-benzyl ester(Boc-L-Glutamic acid 1-benzyl ester) iyinhlanganisela yemvelo enefomula yamakhemikhali engu-C17H19NO6 kanye nesisindo samangqamuzana esihlobene esingu-337.34. Iqinile emhlophe, encibilika kuzincibilikisi zemvelo ezifana ne-ethanol, i-dimethylformamide ne-chloroform.

I-Boc-L-Glutamic acid 1-benzyl ester ivame ukusetshenziswa ekuhlanganiseni ama-peptide compounds. Ingasetshenziswa njenge-ejenti ye-micellar noma iqembu elivikelayo ukuvikela iqembu le-amino acid ukuvimbela ukusabela okungafuneki ohlangothini ekuphenduleni kwamakhemikhali, futhi ngesikhathi esifanayo kungathuthukisa isivuno. Ngaphezu kwalokho, ingasetshenziselwa futhi ukuhlanganiswa kwezidakamizwa ze-polypeptide kanye nama-molecule e-bioactive ahlobene.

Indlela yokulungiselela i-Boc-L-Glutamic acid 1-benzyl ester ngokuvamile iwukwethula iqembu elivikelayo le-Boc eqenjini le-amino le-glutamic acid, kanye nokwenza ukusabela kwe-esterification nge-benzyl anhydride ester kulesi sikhundla. Ukusabela ngokuvamile kwenziwa ngaphansi kwezimo ezingathathi hlangothi noma eziyisisekelo futhi ngokuvamile kudinga inani elithile lesikhathi ukuze kuqinisekiswe ukuqedwa kokusabela. Umkhiqizo otholiwe ungahlanzwa nge-crystallization noma izinyathelo ezengeziwe zokuhlanza.

Mayelana nolwazi lokuphepha, ukuphepha okuqondile kwe-Boc-L-Glutamic acid 1-benzyl ester kudinga ucwaningo olwengeziwe nokuhlolwa. Kodwa-ke, njenge-ejenti yamakhemikhali, ingase ibe nokucasuka okuthile kanye nobuthi. Izinqubo ezifanele zaselabhorethri kufanele zilandelwe ngesikhathi sokuxhumana noma ukusetshenziswa, futhi kufanele kuthathwe izinyathelo zokuphepha ezifanele, okuhlanganisa ukugqokwa kwezinto zokuzivikela (isb., amagilavu ​​elebhu, izibuko zalebhu, njll.). Ngesikhathi sokusetshenziswa noma ukulahlwa, imfucuza kufanele ilahlwe kahle ukuze kugwenywe ukungcoliswa kwemvelo.