BOC-L-Phenylglycine (CAS# 2900-27-8)
| Incazelo Yokuphepha | S22 - Ungaphefumuli uthuli. I-S24/25 - Gwema ukuthintana nesikhumba namehlo. |
| I-WGK Germany | 3 |
| Ikhodi ye-HS | 2924 29 70 |
Isingeniso
I-N-Boc-L-Phenylglycine iyinhlanganisela yezinto eziphilayo ezakhiwe ngokwakhiwa kwesibopho samakhemikhali phakathi kweqembu le-amino (NH2) le-glycine kanye neqembu le-carboxyl (COOH) le-benzoic acid. Ukwakheka kwayo kuqukethe iqembu elivikelayo (iqembu le-Boc), okuyiqembu le-tert-butoxycarbonyl, elisetshenziselwa ukuvikela ukuphinda kusebenze kweqembu le-amino.
I-N-Boc-L-phenylglycine inezindawo ezilandelayo:
- Ukubukeka: Okuqinile kwekristalu emhlophe
- I-Solubility: I-Soluble kwezinye izinyibilikisi ze-organic, njenge-dimethylformamide (DMF), i-dichloromethane, njll.
I-N-Boc-L-phenylglycine ivamise ukusetshenziswa ekuphenduleni kwezinyathelo eziningi ku-organic synthesis, ikakhulukazi ekuhlanganiseni kwezinhlanganisela ze-peptide. Iqembu elivikelayo le-Boc lingavinjelwa izimo ezine-asidi, ukuze iqembu lama-amino likwazi ukusebenza bese lenza ukusabela okulandelayo. I-N-Boc-L-phenylglycine ingasetshenziswa futhi njengokuphuma ekwakhiweni kwezikhungo ze-chiral ku-peptide synthesis.
Ukulungiswa kwe-N-Boc-L-phenylglycine kwenziwa ikakhulukazi ngezinyathelo ezilandelayo:
I-Glycine ifakwe i-benzoic acid ukuze ithole i-benzoic acid-glycinate ester.
Kusetshenziswa ukusabela kwe-lithium borotrimethyl ether (LiTMP), i-benzoic acid-glycinate ester yenziwa i-protonated futhi yasabela nge-Boc-Cl (tert-butoxycarbonyl chloride) ukuze ithole i-N-Boc-L-phenylglycine.
- I-N-Boc-L-phenylglycine ingase icasule amehlo, isikhumba, nendlela yokuphefumula futhi kufanele igwenywe ngesikhathi sokusetshenziswa.
- Izinto zokuzivikela ezifana namagilavu aselabhorethri, izibuko zokuphepha, njll. kufanele zigqokwe ngesikhathi sokusebenza.
- Kufanele wenziwe endaweni yaselabhorethri enomoya omuhle.
- Gwema ukuthintana nama-oxidants nama-asidi aqinile lapho uwagcina.
- Uma ugwinyile noma uhogelwe, funa usizo lwezokwelapha ngokushesha, ulethe isitsha senhlanganisela, futhi unikeze imininingwane yokuphepha edingekayo kudokotela.
