I-Boc-L-Tyrosine methyl ester (CAS# 4326-36-7)

Isingeniso

I-N-Boc-L-Tyrosine I-Methyl Ester iyinhlanganisela yamakhemikhali igama layo lekhemikhali i-N-tert-butoxycarbonyl-L-tyrosine methyl ester. Izici zayo zimi kanje:

1. Ukubukeka: okuqinile kwecrystalline okumhlophe kuya kokumpunga;

5. I-Solubility: i-soluble ku-organic solvents njenge-ethanol ne-dimethylformamide (DMF), engancibiliki emanzini.

I-N-Boc-L-tyrosine methyl ester ivame ukusetshenziswa ku-organic synthesis ukuvikela ama-amino acid ekuhlanganiseni kwezinhlanganisela ze-polypeptide. Ivame ukusetshenziswa njengeqembu elivikelayo le-L-tyrosine ukuvimbela ukusabela okungaqondile ekuphenduleni ukuthi kungenzeki. Uma ukusabela sekuqediwe, iqembu elivikelayo lingasuswa ngaphansi kwezimo ezifanele ukuze kutholwe umkhiqizo ofanele oqondiwe.

Indlela yokulungiselela i-N-Boc-L-tyrosine methyl ester ngokuvamile ihlanganisa lezi zinyathelo ezilandelayo:

1. Hlanganisa i-L-tyrosine ku-dimethylformamide (DMF);

2. Faka i-sodium carbonate ukuze unciphise iqembu le-carboxyl le-tyrosine;

3. I-Methanol ne-methyl carbonate (i-MeOCOCl) yengezwa engxubeni yokusabela ukukhiqiza i-N-Boc-L-tyrosine methyl ester. Ukusabela kuvame ukwenziwa emazingeni okushisa aphansi, futhi i-methyl carbonate eyeqile isetshenziswa ukuze kuqinisekiswe ukuthi ukusabela kuyaqhubeka.

I-N-Boc-L-tyrosine methyl ester izinzile, kodwa isadinga ukuphathwa ngokuqapha. Okulandelayo ulwazi olujwayelekile lokuphepha:

1. Gwema ukuthinta isikhumba namehlo: Amagilavu ​​okuzivikela afanelekile kanye nezibuko kufanele kugqokwe ukuze kugwenywe ukuthintana okuqondile nenhlanganisela;

2. Gwema ukuhogela: Ukungena komoya kahle kufanele kuqinisekiswe endaweni yokusebenza ukuze kuvinjelwe ukuhogela kwamagesi ahlanganisiwe;

3. Isitoreji: Kufanele sigcinwe endaweni epholile, neyomile futhi sigweme ukuthintana nomoya-mpilo, ama-asidi aqinile, noma izisekelo eziqinile.

Sekukonke, i-N-Boc-L-tyrosine methyl ester iyingxenye ebalulekile ekuhlanganiseni kwezinto eziphilayo futhi idlala indima ebalulekile ekuhlanganisweni kwezinhlanganisela ze-peptide. Kufanele kuqashelwe ukusebenza okuphephile lapho usebenzisa futhi uphathwa.