I-Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)

Incazelo Yokuphepha	S22 - Ungaphefumuli uthuli. I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-WGK Germany	3
Ikhodi ye-HS	2924 29 70
I-Hazard Class	I-IRRITANT

I-NAA-tert-butoxycarbonyl N Γ-trityl aspartamide iyinhlanganisela yezinto eziphilayo, evame ukubizwa ngesifinyezo esithi Boc-Phe-OtBu. Inefomula ethi C30H37NO4 futhi iqinile emhlophe.Imvelo:
I-Boc-Phe-OtBu iyi-hydrophobic futhi ayincibiliki kalula emanzini, kodwa incibilika kalula kuzincibilikisi zemvelo ezifana ne-methanol, i-ethanol ne-dichloromethane. Azinzile ekukhanyeni nasekushiseni.

Sebenzisa:
I-Boc-Phe-OtBu isetshenziselwa ikakhulukazi ukuvikela amaqembu kanye nezimaphakathi zokusabela ekuhlanganiseni kwezinto eziphilayo. Ekuhlanganiseni, ingasetshenziswa ukuvikela ama-amino acid anephunga elimnandi, ekuhlanganisweni kwama-polypeptides namaprotheni, ukuvikela amaqembu asebenzayo ukuvimbela ukuvela kokusabela okusemaceleni. Ngaphezu kwalokho, ingasetshenziswa futhi ukulungisa ezinye izinhlanganisela, njengezidakamizwa, odayi kanye nezinto eziphilayo.

Indlela Yokulungiselela:
Ukulungiswa kwe-Boc-Phe-OtBu kwenziwa ikakhulukazi ngokusabela kwamakhemikhali. Indlela eyodwa evamile iwukusabela i-p-benzoic acid ne-t-butyl hydroxyformate ukukhiqiza i-p-tert-butoxycarbonyl benzoate. Kube sekusabela nge-triphenylamine ukunikeza umkhiqizo wokugcina i-Boc-Phe-OtBu.

Ulwazi Lokuphepha:
I-Boc-Phe-OtBu iphephile uma iqhathaniswa nokusetshenziswa okuvamile. Nokho, njengekhemikhali, isadinga ukugcinwa futhi isingathwe ngendlela efanele. Gwema ukuthintana nama-oxidants aqinile, vimbela ukuhogela uthuli futhi ugweme ukuthintana kwesikhumba. Ngesikhathi sokusebenzisa, gqoka izinto zokuzivikela ezifanele, njengamagilavu ​​nezingilazi zokuzivikela. Uma kwenzeka uthintana ngephutha noma udle, funa iseluleko sezokwelapha ngokushesha futhi unikeze ulwazi kudokotela mayelana nekhemikhali. Imithetho nemigomo yokuphepha yendawo kufanele ilandelwe lapho kusingathwa futhi kulahlwa imfucuza.