I-Cbz-Gly-Gly (CAS# 2566-19-0)

Isingeniso

I-N-cbz-gly-gly(N-cbz-gly-gly) iyinhlanganisela ifomula yayo yemolekyuli ithi C18H19N3O6. Okulandelayo yincazelo yemvelo, ukusetshenziswa, ukwakhiwa kanye nolwazi lokuphepha lwe-N-cbz-gly-gly:

Imvelo:

I-N-cbz-gly-gly iyinhlanganisela eqinile, ngokuvamile emhlophe kuya kokuphuzi okukhanyayo noma impushana. Iyazinzile ekamelweni lokushisa futhi inokuncibilika okuphansi.

Sebenzisa:

I-N-cbz-gly-gly iyiqembu elivamile elivikela ama-amino, elisetshenziswa kakhulu emkhakheni we-organic synthesis. Ivamise ukusetshenziswa ekuhlanganiseni kwe-peptide njengeqembu elivikelayo ukuze kuvikelwe isikhashana amaqembu e-amino. Uma kudingekile ukuyisusa, ingavinjelwa kusetshenziswa indlela efanele ukuthola i-peptide oyifunayo.

Indlela:

Ukulungiswa kwe-N-cbz-gly-gly kuvame ukwenziwa yizinyathelo ezilandelayo: Okokuqala, i-glycine yeqembu le-N-protecting isabela nge-glycine ester ukuze ithole i-N-cbz-gly-gly.

Ulwazi Lokuphepha:

Lezi zinyathelo zokuphepha ezilandelayo kufanele zinakwe ngesikhathi sokulungiswa kanye nokusetshenziswa kwe-N-cbz-gly-gly: gwema ukuthintana nesikhumba namehlo. Kunconywa ukuthi ugqoke izinto zokuzivikela ezifana namagilavu ​​nezibuko uma uzisebenzisa. Ngesikhathi esifanayo, kufanele isetshenziswe endaweni yaselabhorethri engenawo umoya ukuze igweme ukuhogela uthuli noma umhwamuko wayo. Ngaphezu kwalokho, kufanele igcinwe endaweni eyomile, epholile, kude nomlilo kanye nama-oxidizing agents.

Sicela uqaphele ukuthi ulwazi olunikeziwe ngenhla olokubhekisela kuphela. Uma udinga ukusebenzisa i-N-cbz-gly-gly noma amanye amakhemikhali, sicela uqinisekise ukuthi kwenziwa ngaphansi kwezimo zokuhlola eziphephile, landela imihlahlandlela efanele yokusebenza nezokuphepha.