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I-Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8) Isithombe Esifakiwe
  • I-Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8) 1

I-Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C20H21NO6
I-Molar Mass 371.38
Ukuminyana 1.268±0.06 g/cm3(Kubikezelwe)
I-Melting Point 92-93?C
I-Boling Point 594.3±50.0 °C(Kubikezelwe)
I-Flash Point 313.2°C
Ukuncibilika kwamanzi Incibilika ku-methanol, i-dimethyl sulfoxide. Incibilika kancane emanzini.
Ukuncibilika I-Soluble ku-Methanol
I-Vapor Presure 5.72E-15mmHg ku-25°C
Ukubukeka I-Crystalline powder
Umbala Emhlophe
pKa 4.47±0.10(Okubikezelwe)
Isimo Sesitoreji Kuvalwe endaweni eyomile, Ngezinga lokushisa Legumbi
I-Refractive Index 1.575
I-MDL I-MFCD00077013

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

 

Isingeniso

I-Z-Glu-OBzl(Z-Glu-OBzl) iyinhlanganisela yemvelo evame ukusetshenziswa njengeqembu elivikelayo lama-amino acid. Okulandelayo incazelo yezakhiwo, ukusetshenziswa, ukulungiswa kanye nolwazi lokuphepha kwenhlanganisela:

 

Imvelo:

-Ifomula yemolekyuli: C17H17NO4

Isisindo samangqamuzana: 303.32g/mol

-Ukubukeka: I-crystalline powder emhlophe

-Indawo yokuncibilika: 84-85°C

-I-Solubility: Incibilika kuma-organic solvents njenge-dimethyl sulfoxide ne-dimethylformamide

- Iqembu elivikelayo le-Cbz lingasuswa nge-palladium hydride catalyst ngaphansi kwezimo ezine-acidic

 

Sebenzisa:

- I-Z-Glu-OBzl iyiqembu elivikelayo le-glutamic acid (Glu), elingasetshenziswa ekuhlanganiseni kokuphuma kwe-amino acid, ama-polypeptides namaprotheni.

-Njengeqembu elivikelayo lama-amino acid kuma-synthetic organic compounds, lingavikela iqembu le-amine le-glutamic acid, livimbele ukuthi lingathinteki ukusabela okungaqondile, futhi lisize ukususwa lapho kudingeka.

 

Indlela Yokulungiselela:

-Ukulungiswa kwe-Z-Glu-OBzl kuvame ukuhlanganisa inqubo enezinyathelo eziningi futhi kuhilela uchungechunge lokusabela kwamakhemikhali. Enye yezindlela ezivamile ukuvikela kuqala iqembu le-carboxyl le-glutamic acid njenge-t-butoxycarbonyl ester (Boc) bese uvikela iqembu lama-amino njenge-Cbz. Ekugcineni, umkhiqizo owufunayo i-Z-Glu-OBzl wakhiwa ngokusabela nge-benzyl chloroformate.

 

Ulwazi Lokuphepha:

- I-Z-Glu-OBzl kufanele iphathwe njengezinhlanganisela ezicasulayo futhi igweme ukuthintana ngqo nesikhumba namehlo.

-Uma kusetshenziswa elabhorethri, kufanele kulandelwe izinqubo zokuphepha ezifanele, okuhlanganisa ukugqoka izibuko zokuzivikela, amagilavu ​​namajazi aselabhorethri.

-Ukuhogela umoya noma ukumunca inhlanganisela kufanele kugwenywe futhi kuthathwe izinyathelo zokuvimbela umlilo nokuqhuma ngesikhathi sokugcina.

-I-compound kufanele ibekwe endaweni enomoya omuhle ngesikhathi sokucutshungulwa, futhi imfucuza kufanele ilahlwe ngendlela efanele ngokuhambisana nemithetho yendawo.

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