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I-Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 ) Isithombe Esifakiwe
  • I-Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 ) 1

I-Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C22H22N4O4
I-Molar Mass 406.43
Ukuminyana 1.34±0.1 g/cm3 (20 ºC 760 Torr)
I-Boling Point 651.6±55.0 °C(Kubikezelwe)
Ukuncibilika I-Chloroform (Kancane), i-DMF (Kancane)
Ukubukeka Okuqinile
Umbala Okumhlophe kuya kokumhlophe
pKa 4.66±0.10(Okubikezelwe)
Isimo Sesitoreji Gcina endaweni emnyama, emkhathini ongangeni, Gcina efrijini, ngaphansi kuka -20°C
Sebenzisa Ophakathi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

 

Isingeniso

Okulandelayo yisingeniso sezakhiwo, ukusetshenziswa, izindlela zokulungiselela kanye nolwazi lokuphepha lwe-apixaban ephakathi kwe-3:

 

Ikhwalithi:

I-Apixaban intermediate 3 iyinhlanganisela yezinto eziphilayo. Iqinile futhi iyancibilika kuzincibilikisi zemvelo njenge-ether ne-ethyl acetate.

 

Ukusetshenziswa: Kuvame ukusetshenziselwa i-anesthesia yokuhlinzwa kanye nokwelashwa kobuhlungu obukhulu.

 

Indlela:

Indlela yokulungiselela ye-apixaban ephakathi kwe-3 ingenziwa ngezinyathelo ezilandelayo: i-p-nitrobenzoic acid isabela nge-hypobutylthiourea lapho kukhona khona i-acetic acid ne-thionyl chloride ukuze kutholwe i-N-(p-nitrophenyl) -N-(hypobutylthioyllurea) i-formic acid, bese, isabela nge-sodium hydroxide ku-sodium oxide nesisombululo se-methanol ukuthola i-apixaban ephakathi 3.

 

Ulwazi Lokuphepha: Izinqubo eziqinile zokusebenza zokuphepha zidinga ukulandelwa lapho kusetshenziswa futhi kusingathwa le nhlanganisela. Ukuthintana ngqo noma ukuhogela kungadala umonakalo omkhulu empilweni yomuntu. Ulwazi oluqondile lwayo lokuphepha kufanele luhlolwe futhi lucutshungulwe ngokuhambisana nemithethonqubo efanele kanye neziqondiso ukuze kuqinisekiswe ukusetshenziswa nokuphathwa okuphephile. Lapho kwenziwa izivivinyo zokuhlanganiswa kwamakhemikhali, kufanele zisetshenziswe ngaphansi kwezimo ezifanele zaselabhorethri kanye nezinto zokuzivikela zomuntu siqu njengezibuko zamakhemikhali, amagilavu ​​okuzivikela, nezingubo zokuzivikela kufanele zisetshenziswe.

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