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I-Fmoc-2-Amino-2-methylpropionic acid (CAS# 94744-50-0) Isithombe Esifakiwe
  • I-Fmoc-2-Amino-2-methylpropionic acid (i-CAS# 94744-50-0) 1

I-Fmoc-2-Amino-2-methylpropionic acid (i-CAS# 94744-50-0)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C19H19NO4
I-Molar Mass 325.36
Ukuminyana 1.256±0.06 g/cm3(Kubikezelwe)
I-Melting Point 182-188°C
I-Boling Point 544.3±33.0 °C(Kubikezelwe)
Ukubukeka I-crystalline powder emhlophe
Umbala Okumhlophe kuya Kucishe kube mhlophe
I-BRN 5604328
pKa 3.98±0.10(Okubikezelwe)
Isimo Sesitoreji 2-8°C
Kuyazwela Kuyazwela Umswakama
I-Refractive Index 1.614
I-MDL I-MFCD00151913

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Incazelo Yokuphepha S22 - Ungaphefumuli uthuli.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-WGK Germany 3
AMAKHODI E-FLUKA BRAND F 10-21
Ikhodi ye-HS 29242990
I-Hazard Class I-IRRITANT

 

Isingeniso

I-Fmoc-2-aminoisobutyric acid, eyaziwa nangokuthi i-Fmoc-Aib, iyinhlanganisela yezinto eziphilayo. Okulandelayo isingeniso esinemininingwane kwezinye izakhiwo, ukusetshenziswa, izindlela zokulungiselela kanye nolwazi lokuphepha lwe-Fmoc-2-aminoisobutyric acid:

 

Ikhwalithi:

I-Fmoc-2-aminoisobutyric acid iyikristale eqinile emhlophe enephunga elingavamile. Iyazinzile ekamelweni lokushisa futhi ayincibiliki emanzini, kodwa incibilika kuzincibilikisi eziphilayo njenge-methanol ne-methylene chloride.

 

Sebenzisa:

I-Fmoc-2-aminoisobutyric acid iyiqembu elivikelayo elivame ukusetshenziswa ku-organic synthesis. Ingasetshenziswa njengeqembu ukuze kuvikelwe okwesikhashana amaqembu e-amino kuma-polypeptides okwenziwa namaprotheni ukuze awavimbele ekuphenduleni okuseceleni ekuphenduleni kwamakhemikhali.

 

Indlela:

Indlela yokulungiselela ye-FMOC-2-aminoisobutyric acid ngokuvamile yenziwa ngamakhemikhali. Lokhu ngokuvamile kwenziwa ukusabela kwe-2-aminoisobutyric acid nge-Fmoc-OSu (Fmoc-N-hydroxysuccinimidyl) noma i-Fmoc-OXy (Fmoc-N-hydroxysuccinimidate). Ukusabela kuvame ukuqhutshwa ekamelweni lokushisa futhi kuhlanjululwe ngokukhipha i-solvent kanye ne-crystallization.

 

Ulwazi Lokuphepha:

I-FMOC-2-aminoisobutyric acid ngokuvamile iphephe kakhulu ngaphansi kwezimo ezijwayelekile zokusetshenziswa. Njengenhlanganisela yezinto eziphilayo, kungase kube yingozi ethile empilweni yomuntu. Kufanele kuqashelwe ukugwema ukuhogela izimpushana noma izixazululo ngenkathi ugwema ukuthintana nesikhumba namehlo. Amagilavu ​​okuzivikela, izibuko, nezifihla-buso kufanele kugqokwe uma kunesidingo. Uma uthinta isikhumba noma amehlo, geza ngokushesha ngamanzi amaningi futhi ufune usizo lwezokwelapha. Kufanele igcinwe endaweni eyomile, epholile, kude nomlilo nama-oxidants.

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