I-Fmoc-D-3-Cyclohexyl Alanine (CAS# 144701-25-7)
Ubungozi Nokuphepha
| Incazelo Yokuphepha | S22 - Ungaphefumuli uthuli. I-S24/25 - Gwema ukuthintana nesikhumba namehlo. |
| I-WGK Germany | 3 |
| AMAKHODI E-FLUKA BRAND F | 10 |
| Ikhodi ye-HS | 2924 29 70 |
| I-Hazard Class | I-IRRITANT |
Isingeniso
I-Fmoc-D-3-Cyclohexyl Alanine (CAS# 144701-25-7), evame ukubizwa ngokuthi i-Fmoc-D-amino acid, iyinhlanganisela yezinto eziphilayo. Itholakala ngokungeza iqembu le-methoxycarbonyl eqenjini le-amino le-fmoc-3-cyclohexyl-D-alanine.
Ngokuphathelene nezakhiwo ze-FMOC-D-amino acid, iyisisombululo esiqinile noma sokulandelela esingancibilika kwezinye izinyibilikisi zemvelo, njenge-dimethyl sulfoxide (DMSO) ne-methanol (MeOH). Inezici ezinamandla zokumunca i-UV, ekhombisa ukumuncwa okuphezulu ebangeni lama-240-245 nm.
I-FMOC-D-amino acid inohlu olubanzi lwezinhlelo zokusebenza ocwaningweni lwe-biochemical. Okunye okuvame ukusetshenziswa njengeqembu elivikelayo lama-solid-phase synthetase peptides nama-polypeptides, avikela ama-hydroxyl noma amaqembu ama-amino ngesikhathi sokuhlanganiswa. Ngaphezu kwalokho, ingase isetshenziselwe ukuhlanganiswa kwezinto eziphilayo ezisebenzayo ze-steroid kanye nokulungiswa kwama-peptide noma amaprotheni okulandelana okuqondile.
Indlela evamile yokulungiselela i-FMOC-D-amino acid iwukwengeza i-FMOC chlorinating reagent eqenjini le-amino le-fmoc-3-cyclohexyl-D-alanine, futhi wenze ukusabela esimweni esifanele sokunyibilikisa nokusabela. Ngemuva kwalokho, umkhiqizo owufunayo ungatholwa ngezinyathelo ezifanele zokuhlanza ezifana nokukhipha i-solvent kanye nekholomu chromatography.
Mayelana nolwazi lokuphepha, ama-FMOC-D-amino acid aphephe kakhulu ngaphansi kwezimo ezijwayelekile zokusebenza. Nokho, kusadingeka ukuthi kuthathwe izinyathelo zokuphepha ezifanele zaselabhorethri, njengokugqoka izinto zokuzivikela ezifanele kanye nokusebenza endaweni yaselabhorethri enomoya omuhle. Ngaphezu kwalokho, ngokwemibandela ethile yelabhorethri ngayinye, izinqubo ezifanele zokusebenza zokuphepha kanye nezinyathelo zokuphepha kufanele zilandelwe ngesikhathi sokusetshenziswa nokuphathwa.
Ngokuphathelene nezakhiwo ze-FMOC-D-amino acid, iyisisombululo esiqinile noma sokulandelela esingancibilika kwezinye izinyibilikisi zemvelo, njenge-dimethyl sulfoxide (DMSO) ne-methanol (MeOH). Inezici ezinamandla zokumunca i-UV, ekhombisa ukumuncwa okuphezulu ebangeni lama-240-245 nm.
I-FMOC-D-amino acid inohlu olubanzi lwezinhlelo zokusebenza ocwaningweni lwe-biochemical. Okunye okuvame ukusetshenziswa njengeqembu elivikelayo lama-solid-phase synthetase peptides nama-polypeptides, avikela ama-hydroxyl noma amaqembu ama-amino ngesikhathi sokuhlanganiswa. Ngaphezu kwalokho, ingase isetshenziselwe ukuhlanganiswa kwezinto eziphilayo ezisebenzayo ze-steroid kanye nokulungiswa kwama-peptide noma amaprotheni okulandelana okuqondile.
Indlela evamile yokulungiselela i-FMOC-D-amino acid iwukwengeza i-FMOC chlorinating reagent eqenjini le-amino le-fmoc-3-cyclohexyl-D-alanine, futhi wenze ukusabela esimweni esifanele sokunyibilikisa nokusabela. Ngemuva kwalokho, umkhiqizo owufunayo ungatholwa ngezinyathelo ezifanele zokuhlanza ezifana nokukhipha i-solvent kanye nekholomu chromatography.
Mayelana nolwazi lokuphepha, ama-FMOC-D-amino acid aphephe kakhulu ngaphansi kwezimo ezijwayelekile zokusebenza. Nokho, kusadingeka ukuthi kuthathwe izinyathelo zokuphepha ezifanele zaselabhorethri, njengokugqoka izinto zokuzivikela ezifanele kanye nokusebenza endaweni yaselabhorethri enomoya omuhle. Ngaphezu kwalokho, ngokwemibandela ethile yelabhorethri ngayinye, izinqubo ezifanele zokusebenza zokuphepha kanye nezinyathelo zokuphepha kufanele zilandelwe ngesikhathi sokusetshenziswa nokuphathwa.
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