I-FMOC-D-NVA-OH (CAS# 144701-24-6)

I-FMOC-D-NVA-OH (CAS# 144701-24-6) iyiqembu elivikela ama-amino acid elivame ukusetshenziswa ekuhlanganiseni ama-peptides namaprotheni. Okulandelayo yincazelo yemvelo, ukusetshenziswa, ukwakhiwa kanye nolwazi lokuphepha lwe-fmoc-D-norvaline:

Imvelo:
I-fmoc-D-norvaline iqinile emhlophe, ngokuvamile isesimweni sempushana. Incibilika kahle kuma-ejenti ancibilikayo njenge-N,N-dimethylformamide (DMF) noma i-dichloromethane (DCM). I-compound inokuzinza okuphezulu kwe-thermal futhi ingaba izinzile kuma-solvents avamile we-organic.

Sebenzisa:
I-fmoc-D-norvaline isetshenziswa kakhulu njengeqembu elivikela ama-amino acid ekuhlanganiseni ama-peptides namaprotheni. Ingaxhunyaniswa namanye ama-amino acid ngokuhlanganiswa kwesigaba esiqinile, esingavikela okwesikhashana amanye ama-amino acid ngesikhathi sokuhlanganiswa. Uma i-peptide chain synthesis isiqediwe, iqembu elivikelayo le-Fmoc lingasuswa ngokwelashwa okuyisisekelo.

Indlela:
I-fmoc-D-norvaline ivamise ukulungiselelwa ukuhlanganiswa kwamakhemikhali, ne-D-norvaline njengento yokuqala. I-synthesis ihlanganisa ukusabela kwe-norvaline neqembu elivikelayo le-Fmoc ukwethula iqembu le-Fmoc ngokusabela okungena esikhundleni. Ekugcineni thola i-fmoc-D-norvaline.

Ulwazi Lokuphepha:
I-fmoc-D-norvaline iphephile uma kuqhathaniswa ngaphansi kwezimo ezijwayelekile zokusebenza zelabhorethri, ezinye izinqubo zokusebenza eziyisisekelo zisadinga ukulandelwa. Gwema ukuthinta isikhumba namehlo ngenkathi usebenzisa, futhi qinisekisa ukuthi usebenza endaweni enomoya omuhle. Izinto zokuzivikela ezifanele, njengamagilavu ​​zelabhu nezibuko zokuphepha, kufanele zigqokwe lapho uphatha inhlanganisela. Ngaphezu kwalokho, imfucuza kufanele ilahlwe ngendlela efanele futhi ilahlwe ngokuhambisana nemithethonqubo efanele. Uma kwenzeka ingozi yengozi, izinyathelo zosizo lokuqala ezihambisanayo kufanele zithathwe ngokushesha. Ekusetshenzisweni nasekugcinweni kwe-fmoc-D-norvaline, imithetho efanele yokuphepha kwamakhemikhali kufanele ilandelwe.