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I-FMOC-Glycine (CAS# 29022-11-5) Isithombe Esifakiwe
  • FMOC-Glycine (CAS# 29022-11-5) 1

FMOC-Glycine (CAS# 29022-11-5)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C17H15NO4
I-Molar Mass 297.31
Ukuminyana 1.1671 (isilinganiso esinzima)
I-Melting Point 174-175°C(lit.)
I-Boling Point 438.82°C (isilinganiso esinzima)
I-Flash Point 283.8°C
Ukuncibilika cishe obala ku-Methanol
I-Vapor Presure 9.69E-13mmHg ku-25°C
Ukubukeka Amakristalu amhlophe kuya kokuphuzi
Umbala Emhlophe
I-BRN 2163967
pKa 3.89±0.10(Okubikezelwe)
Isimo Sesitoreji 2-8°C
I-Refractive Index 1.4500 (isilinganiso)
I-MDL I-MFCD00037140
Sebenzisa Isetshenziselwa ama-reagents e-biochemical, i-peptide synthesis.

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi Xi - Irritant
Amakhodi Engozi 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
S36 – Gqoka izingubo ezifanele zokuzivikela.
S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-WGK Germany 3
Ikhodi ye-HS 29242995

 

Isingeniso

I-N-Fmoc-glycine iyingxenye ebalulekile ye-amino acid, futhi igama layo lekhemikhali yi-N-(9H-fluoroeidone-2-oxo) -glycine. Okulandelayo yisingeniso sezakhiwo, ukusetshenziswa, izindlela zokulungiselela kanye nolwazi lokuphepha lwe-N-Fmoc-glycine:

 

Ikhwalithi:

- Ukubukeka: Okuqinile okumhlophe noma okumhlophe

- Ukunyibilika: Kuncibilika kuzincibilikisi eziphilayo njenge-dimethyl sulfoxide (DMSO) ne-methylene chloride, encibilika kancane otshwaleni, cishe engancibiliki emanzini.

 

Sebenzisa:

I-N-Fmoc-glycine isetshenziselwa ikakhulukazi ukuhlanganiswa kwe-peptide ku-solid-phase synthesis (SPPS). Njenge-amino acid evikelwe, yengezwa ochungechungeni lwe-polypeptide ngokuhlangana kwesigaba esiqinile, futhi ekugcineni i-peptide eqondiwe itholakala ngokusabela kwamaqembu avikelayo.

 

Indlela:

Ukulungiswa kwe-N-Fmoc-glycine kuvame ukwenziwa ukusabela kwamakhemikhali. I-Glycine isabela nge-N-fluorophenyl methyl alcohol kanye nesisekelo (isb, i-triethylamine) ukukhiqiza i-N-fluorophenylmethyl-glycine hydrochloride. Bese, i-hydrochloric acid isuswa uhlobo oluthile lwe-deacidifier, njenge-dimethyl sulfoxide noma i-sec-butanol, ukunikeza i-N-Fmoc-glycine.

 

Ulwazi Lokuphepha:

I-N-Fmoc-Glycine iphephile uma kuqhathaniswa ngaphansi kwezimo ezijwayelekile zokusebenza

- Sicela ugqoke izinto zokuzivikela ezifanele ezifana namagilavu ​​zelabhu nokuvikela amehlo.

- Gwema ukuhogela umoya noma ukuthintana nesikhumba namehlo.

- Landela yonke imithetho yokuphepha efanele kanye nezimiso zaselabhorethri lapho ugcina futhi uphatha.

- Naka ukunqwabelana komlilo kanye nogesi omile phakathi nenqubo yokuphatha ukuze uvimbele ingozi yomlilo nokuqhuma.

- Ukulahlwa kahle kwemfucuza ngokuhambisana nezidingo zokugcinwa nokulahlwa kwezinto.

 

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