I-Fmoc-L-Aspartic acid-1-benzyl ester (CAS# 86060-83-5)

Isingeniso

I-Fmoc-Asp-OBzl(Fmoc-Asp-OBzl) iyinhlanganisela esetshenziswa kakhulu ekuhlanganiseni kwe-peptide kanye nokuhlanganisa kwesigaba esiqinile.

Imvelo:

I-Fmoc-Asp-OBzl iyikristale eqinile emhlophe enokuncibilika okuhle nokuzinza. Ifomula yayo yamakhemikhali yi-C33H29NO7 futhi isisindo sayo samangqamuzana singama-555.6. Ineqembu elivikela i-fluorenyl (Fmoc) kanye neqembu elivikela i-benzoyl (Bzl) ukuvikela i-aspartic acid.

Sebenzisa:

I-Fmoc-Asp-OBzl njengeqembu elivikelayo ingasetshenziswa ekuhlanganiseni ama-peptides namaprotheni. Ingasetshenziswa kuhlelo oluqinile lokwenziwa kwesigaba kanye nesinyathelo sokususwa kweqembu elivikelayo ekuphenduleni kokuhlanganiswa kwe-peptide. Ekuhlanganiseni, insalela ye-aspartic acid ingase ivikelwe i-Fmoc-Asp-OBzl esiqeshini se-peptide esiwumphumela ukuvimbela ukusabela okungafuneki.

Indlela Yokulungiselela:

Ukulungiswa kwe-Fmoc-Asp-OBzl ngokuvamile kwenziwa ngokuhlanganisa amakhemikhali. Ngokuqondile, i-Fmoc-Asp-OBzl ingatholwa ngokusabela i-fluorenecyl chloride (Fmoc-Cl) nge-aspartic acid -1-benzyl ester (Asp-OBzl).

Ulwazi Lokuphepha:

I-Fmoc-Asp-OBzl ikhemikhali edinga ukuphathwa elabhorethri. Landela izinqubo zokuphepha ezifanele zaselabhorethri ngesikhathi sokuphatha, njengokugqoka izinto zokuzivikela ezifanele (njengamagilavu, izibuko, namajazi aselabhorethri) ukuze ugweme ukuthinta isikhumba, amehlo, nemigudu yokuphefumula. Ngaphezu kwalokho, kufanele igcinwe endaweni eyomile, epholile, futhi kude nomlilo nezinto ezivuthayo. Uma usebenzisa i-Fmoc-Asp-OBzl, kufanele kuqashelwe ubuthi bayo nokucasuka, futhi kuqinisekiswe ukuthi isetshenziswa endaweni ephephile.