I-Fmoc-L-Glutamic acid 1-tert-butyl ester (CAS# 84793-07-7)

Isingeniso

I-Fluorene methoxycarbonyl-L-glutamate-1-tert-butyl ester, eyaziwa nangokuthi i-Fmoc-L-glutamic acid-1-tert-butyl ester, ingxube ye-organic evame ukusetshenziswa ekuhlanganiseni kwe-peptide kanye nokuhlanganiswa kwesigaba esiqinile ekuhlanganiseni kwezinto eziphilayo.

Ikhwalithi:

I-Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl iqinile enamakristalu amhlophe kuya kokuphuzi. Inoncibilika kancane emanzini kodwa i-solubility enhle kuzincibilikisi zemvelo njenge-dimethyl sulfoxide noma i-methanol.

Sebenzisa:

I-Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl iyi-amino acid evikelayo evame ukusetshenziswa ekuhlanganiseni kwe-peptide. Ingasetshenziselwa ukuvikela iqembu ngokusabela, ukuze livezwe ekuhlanganiseni nasekuthuthukisweni kweketango le-peptide. Le nhlanganisela ifaneleka ikakhulukazi ukuhlanganiswa kwesigaba esiqinile, lapho amaketanga e-peptide ehlanganiswa nama-amino acid avikelayo emagatsheni e-resin.

Indlela:

Ukulungiswa kwe-fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl kuvame ukufezwa ngokuhlanganiswa kwamakhemikhali. I-fluorene methanol iqala ukuhlanganiswa ibe yi-fluorene carboxyl chloride ngokusabela kwamakhemikhali, bese isabela nge-L-glutamic acid ukuze yakhe i-fluorene methoxycarbonyl-L-glutamic acid, futhi ekugcineni iphendule nge-tert-butanol ukwenza umkhiqizo wokugcina.

Ulwazi Lokuphepha:

I-fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl ngokuvamile ibhekwa njengengenabo ubuthi obusobala kubantu ngaphansi kwezimo ezijwayelekile zokuhlola. Izimiso zokuphepha ezifanele zaselabhorethri zidinga ukulandelwa ngesikhathi sokuphatha, okuhlanganisa ukugqoka amagilavu ​​okuzivikela nezibuko, nokusebenza ngaphansi kwezimo ezinomoya omuhle.