I-Fmoc-L-glutamic acid-gamma-benzyl ester (CAS# 123639-61-2)

I-Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl iyinhlanganisela yemvelo esetshenziswa ekuhlanganiseni kwe-peptide ekuhlanganiseni kwesigaba esiqinile. Imvelo yayo:
- Ukubukeka: Okuqinile okumhlophe kuya kokuphuzi okuphaphathekile
- I-Solubility: I-Fmoc-L-Glu(OtBu)-OH inokuncibilika okuhle phakathi kwezincibilikisi ezivamile zemvelo.

Ukusetshenziswa okuyinhloko kwe-Fmoc-L-Glu (OtBu)-OH njengeqembu elivikelayo ekuhlanganiseni kwe-peptide. Lapho kuhlanganiswa amaketanga e-peptide, i-Fmoc-L-Glu(OtBu)-OH ibophezela kuma-amino acid, ivikela umsebenzi wawo ekuphenduleni okungaqondile nokunye okusabelayo. Ngemva kokuqedwa kokusabela, i-Fmoc-L-Glu(OtBu)-OH ingasuswa ngokususa iqembu elivikelayo ukuze kubuyiselwe umsebenzi wama-amino acid.

Ukulungiswa kwe-Fmoc-L-Glu(OtBu)-OH kuyinkimbinkimbi futhi ngokuvamile kudinga ukusetshenziswa kochungechunge lwezinyathelo ze-organic synthesis. I-Glutamic acid isabela nge-bromoacetate ukuze ithole i-ethyl glutamate. Khona-ke, i-ethyl glutamate isabela nge-benzyl utshwala ukuze yakhe i-ethyl glutamate benzyl alcohol ester. I-Ethyl glutamate benzyl alcohol ester yaphendulwa nge-Fmoc-Cl ukuze kukhiqizwe umkhiqizo oqondiwe we-Fmoc-L-Glu(OtBu)-OH.

Ulwazi Lokuphepha: I-Fmoc-L-Glu(OtBu)-OH umuthi waselabhorethri futhi udinga ukusetshenziswa ngaphansi kokusebenza kwaselabhorethri okuphephile. Landela izinqubo ezijwayelekile zokuphepha zaselabhorethri, okuhlanganisa ukugqoka izinto zokuzivikela (isb, amagilavu ​​zelabhu, izibuko, njll.), ukugwema ukuthintana kwesikhumba nokuhogela, kanye nokusebenza elabhorethri enomoya omuhle. I-compound kufanele igcinwe esitsheni esingangeni moya, kude nokushisa kanye nama-oxidants.