I-Fmoc-L-homophenylalanine (CAS# 132684-59-4)
Ubungozi Nokuphepha
| Izimpawu Eziyingozi | Xi - Irritant |
| Amakhodi Engozi | 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba. |
| Incazelo Yokuphepha | S22 - Ungaphefumuli uthuli. I-S24/25 - Gwema ukuthintana nesikhumba namehlo. I-S44 - S35 – Le nto kanye nesiqukathi sayo kumele kulahlwe ngendlela ephephile. I-S28 – Ngemva kokuxhumana nesikhumba, geza ngokushesha ngensipho eningi. I-S7 – Gcina isitsha sivalwe ngokuqinile. I-S4 - Gcina kude nezindawo zokuhlala. |
| I-WGK Germany | 3 |
| Ikhodi ye-HS | 2924 29 70 |
| I-Hazard Class | I-IRRITANT |
Isingeniso
2. Ukunyibilika: Kuncibilika kuzincibilikisi eziphilayo njenge-dimethyl sulfoxide (DMSO) ne-ethyl acetate (EtOAc), engancibiliki emanzini.
3. ifomula yamangqamuzana: C32H29NO4.
4. isisindo samangqamuzana: 495.58.
Ukusetshenziswa okuyinhloko kwe-Fmoc-L-homophenylalanine kunjengeqembu elivikelayo ekuhlanganiseni kwe-peptide. I-Fmoc isifinyezo se-furoyl kanye nokuphuma kwayo, okungavikela iqembu lama-amino kuma-amino acid. Uma kufiswa ukuhlanganiswa kweketango le-peptide, iqembu le-amino lingenziwa litholakale ukuze kuphenduleke ngokususa iqembu elivikelayo le-Fmoc. Ngakho-ke, i-Fmoc-L-homophenylalanine idlala indima ebalulekile ekulungiseleleni izidakamizwa ze-peptide kanye nama-molecule e-bioactive ahlobene.
Indlela yokulungiselela ye-Fmoc-L-homophenylalanine iyinkimbinkimbi futhi ibandakanya ukusabela kokuhlanganiswa kwezinyathelo eziningi. Indlela evamile yokulungiselela iwukusabela ngokuhlanganyela i-Fmoc-protected phenylalanine namanye ama-reagents, njenge-silver azide formate (AgNO2), elandelwa ukwelashwa kwe-trifluoroacetic acid ukunikeza i-Fmoc-L-homophenylalanine.
Ulwazi olulandelayo lokuphepha kufanele luqashelwe uma usebenzisa i-Fmoc-L-homophenylalanine:
1. gwema ukuthintana ngqo nesikhumba, amehlo kanye nolwelwesi lwamafinyila, ngoba kungase kucasule umzimba womuntu.
2. Isitoreji kufanele sigweme ukuthintana nama-oxidants aqinile noma ama-asidi aqinile ukuvimbela ukusabela okuyingozi.
3. Sebenzisa izinto zokuzivikela ezifanele ezifana namagilavu, izibuko zokuzivikela namajazi aselabhorethri ngesikhathi sokusetshenziswa nokuphatha.
4. Yonke imisebenzi kufanele yenziwe ngaphansi kwezimo zaselabhorethri ezinomoya omuhle.
Kafushane, i-Fmoc-L-homophenylalanine iyiqembu elivikela i-amino acid elivame ukusetshenziswa ekuhlanganiseni kwe-peptide futhi linohlelo olubanzi lwezinhlelo zokusebenza. Lapho usebenzisa futhi uphatha i-compound, kuyadingeka ukunaka ukuphatha nokugcinwa okuphephile.
