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I-Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3) Isithombe Esifakiwe
  • I-Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3) 1

I-Fmoc-O-tert-butyl-L-tyrosine (CAS# 71989-38-3)

Isakhiwo Samakhemikhali:

I-Molecular Formula C28H29NO5
I-Molar Mass 459.53
Ukuminyana 1.218±0.06 g/cm3(Kubikezelwe)
I-Melting Point ~150°C (dec.)
I-Boling Point 658.2±55.0 °C(Kubikezelwe)
Ukuzungezisa Okuthile(α) -28 º (c=1, DMF)
I-Flash Point 351.9°C
Ukuncibilika I-Chloroform (Kancane), i-DMF (Kancane), i-Methanol (Kancane)
I-Vapor Presure 3.2E-18mmHg ku-25°C
Ukubukeka Ikristalu elimhlophe
Umbala Emhlophe
I-BRN 4216652
pKa 2.97±0.10(Okubikezelwe)
Isimo Sesitoreji Gcina ngaphansi kuka +30°C.
I-Refractive Index -30 ° (C=1, DMF)
I-MDL I-MFCD00037129
Izakhiwo Zomzimba Nezamakhemikhali I-crystalline powder emhlophe; Ayincibiliki emanzini naku-petroleum ether, encibilika ku-ethyl acetate, i-methanol ne-DMF;mp ingu-150-151 ℃; Ukujikeleza okuqondile kokubona [α]20D 10 5.2 °(0.5-2.0 mg/ml, ethyl acetate),[α]20D-27.6 °(0.5-2.0 mg/ml,DMF),[α]20D-6 °(0.5- 2.0 mg/ml, i-methanol).

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi Xi - Irritant
Amakhodi Engozi 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-WGK Germany 3
Ikhodi ye-HS 2924 29 70

 

Isingeniso

I-fluorene methoxycarbonyl-oxotert-butyl-tyrosine iyinhlanganisela yamakhemikhali evame ukufushaniswa njenge-FMOC-Tyr(tBu)-OH. Okulandelayo yisingeniso semvelo yayo, ukusetshenziswa, ukulungiswa kanye nolwazi lokuphepha:

 

Ikhwalithi:

- Ukubukeka: Okuqinile okumhlophe noma okumhlophe.

- Ukunyibilika: Kuncibilika kwezinye izinyibilikisi zemvelo, njenge-dimethyl sulfoxide ne-dimethylformamide.

 

Sebenzisa:

- Ukuvikela amaqembu ekuhlanganiseni kwamakhemikhali: Amaqembu e-FOC angasetshenziswa ukuvikela amaqembu e-amino kuma-phenolic compounds ukuze awavimbele ukuthi angaphenduli. I-FMOC-Tyr(tBu)-OH ingasetshenziswa njengesiqalo sokulungiswa kwamaketanga e-peptide ekuhlanganiseni kwamakhemikhali.

 

Indlela:

Indlela yokulungiselela ye-FOC-Tyr(tBu)-OH ingafinyelelwa ngalezi zinyathelo ezilandelayo:

- I-Fluorenyl chloride (FMOC-Cl) iphendulwa nge-tert-butyl (tBu-NH2) ukuze inikeze i-fluorenylmethoxycarbonyl-tert-butichsyl (FMOC-tBu-NH-).

- Bese, phendula umphumela we-FOC-tBu-NH- nge-tyrosine (Tyr-OH) ukukhiqiza i-FMOC-Tyr(tBu)-OH.

 

Ulwazi Lokuphepha:

- Ukusetshenziswa kwe-FMOC-Tyr (tBu)-OH kungaphansi kokuthobela izimiso zokuphepha zaselabhorethri.

- Gwema ukuthinta isikhumba namehlo, futhi gqoka amagilavu ​​okuzivikela kanye nezibuko lapho usebenzisa.

- Sebenzisa endaweni enomoya omuhle, kude nomlilo nezinto ezivuthayo.

- Akumele ikhishelwe endaweni ezungezile futhi kufanele iphathwe futhi ilahlwe ngokuhambisana nemithetho yendawo.

 

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