I-L-Pyroglutamic acid CAS 98-79-3
Ubungozi Nokuphepha
| Izimpawu Eziyingozi | Xi - Irritant |
| Amakhodi Engozi | 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba. |
| Incazelo Yokuphepha | S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha. S36 – Gqoka izingubo ezifanele zokuzivikela. I-S37/39 – Gqoka amagilavu afanelekile kanye nokuvikela iso/ubuso |
| I-WGK Germany | 3 |
| I-RTECS | TW3710000 |
| AMAKHODI E-FLUKA BRAND F | 21 |
| I-TSCA | Yebo |
| Ikhodi ye-HS | 29337900 |
| Isingeniso | I-pyroglutamic acid yi-5-oxyproline. Yakhiwe ngokuphelelwa amanzi emzimbeni phakathi kweqembu le-α-NH2 kanye neqembu le-γ-hydroxyl le-glutamic acid ukuze kwakhiwe isibopho se-lactam yamangqamuzana; Ingabuye yakhiwe ngokulahlekelwa iqembu le-Amido ku-molecule ye-glutamine. Uma ukuntula kwe-glutathione synthetase, kungabangela i-pyroglutamemia, uchungechunge lwezimpawu zomtholampilo. I-Pyroglutamemia ukuphazamiseka kwe-organic acid metabolism okubangelwa ukushoda kwe-glutathione synthetase. Ukubonakaliswa komtholampilo kokuzalwa kwamahora angu-12 ~ 24 okuqala, i-hemolysis eqhubekayo, i-jaundice, i-Metabolic Acidosis engapheli, ukuphazamiseka kwengqondo, njll.; Umchamo uqukethe i-pyroglutamic acid, i-lactic acid, i-Alpha deoxy4 glycoloacetic acid lipid. Ukwelashwa, uphawu, qaphela ukulungisa ukudla ngemva kweminyaka yobudala. |
| izakhiwo | I-L-pyroglutamic acid, eyaziwa nangokuthi i-L-pyroglutamic acid, i-L-pyroglutamic acid. Kusukela kungxube ye-ethanol ne-petroleum ether emvula ye-orthorhombic double cone Crystal engenambala, indawo encibilikayo engu-162~163 ℃. Incibilika emanzini, utshwala, i-acetone ne-acetic acid, i-ethyl acetate-soluble, engancibiliki ku-ether. Ukujikeleza okuqondile kokubona -11.9 °(c = 2,H2O). |
| Izici kanye nokusetshenziswa | esikhumbeni somuntu kuqukethe umsebenzi wokuthambisa wezinto ezincibilikayo emanzini-isici sokuthambisa semvelo, ukwakheka kwayo cishe ku-amino acid (equkethe ama-40%), i-pyroglutamic acid (equkethe i-12%), usawoti we-inorganic (Na, K, Ca, Mg, njll. equkethe 18.5%), kanye nezinye izinhlanganisela eziphilayo (eziqukethe 29.5%). Ngakho-ke, i-pyroglutamic acid ingenye yezingxenye eziyinhloko zesici semvelo esithambisa isikhumba, futhi amandla ayo okuthambisa adlula kude lawo e-glycerol ne-propylene glycol. Futhi okungezona ubuthi, akukho okushukumisayo, Ukunakekelwa Kwesikhumba kwesimanje, izimonyo Zokunakekelwa Kwezinwele ezinhle kakhulu. I-Pyroglutamic acid nayo inomphumela ovimbelayo emsebenzini we-tyrosine oxidase, ngaleyo ndlela ivimbele ukufakwa kwezinto "ze-melanoid" esikhumbeni, okunomthelela omhlophe esikhumbeni. Inomphumela wokuthambisa esikhumbeni, ingasetshenziselwa izimonyo zezinzipho. Ngokungeziwe ekusetshenzisweni kwezimonyo, i-L-pyroglutamic acid ingaphinda ikhiqize okuphuma kwamanye ama-organic compounds, anemiphumela ekhethekile emsebenzini ongaphezulu, umphumela obala futhi okhanyayo, njll. Ingasetshenziswa futhi njenge-surfactant ye-detergents; Ama-reagents amakhemikhali wokuxazulula ama-amine e-racemic; Organic intermediates. |
| indlela yokulungiselela | I-L-pyroglutamic acid yenziwa ngokukhipha umzuzu owodwa wamanzi ku-molecule ye-L-glutamic acid, futhi inqubo yayo yokulungiselela ilula, izinyathelo eziyinhloko ziwukulawula izinga lokushisa kanye nesikhathi sokuqeda amanzi. (1) U-500g we-L-glutamic acid wanezelwa kubhekha we-100 ml, futhi ibhekha yashiswa ngokugeza ngamafutha, futhi izinga lokushisa lakhushulwa laya ku-145 kuya ku-150 ° C., futhi izinga lokushisa lagcinwa imizuzu engu-45 ukuze kuphelelwe amanzi emzimbeni. ukusabela. Isixazululo esiphelelwe amanzi kwakungu-Tan. (2) ngemva kokuphothulwa kokusabela kokuphelelwa amanzi emzimbeni, isixazululo sithelwa emanzini abilayo ngevolumu engaba ngu-350, futhi isisombululo saqedwa ngokuphelele emanzini. Ngemva kokupholisa ku-40 kuya ku-50 ° C., inani elifanele lekhabhoni ecushiwe lengeziwe ukuze kukhishwe umbala (okuphindaphindiwe kabili). Kutholwe isixazululo esisobala esingenambala. (3) lapho isixazululo esingenambala esisobala esilungiselelwe esinyathelweni (2) sishisiswa ngokuqondile futhi sihwamuke ukuze kuncishiswe umthamo ube cishe uhhafu, phendukela kubhavu wamanzi futhi uqhubeke nokugxila kumthamo we-1/3, ungayeka ukushisisa, futhi emanzini ashisayo okugeza ukuze kuncishiswe ukucwebezela, amahora angu-10 kuya kwangu-20 ngemva kokulungiswa kwamakristalu eprismatic angenambala. Inani le-L-pyroglutamic acid ezimonyoni lincike ekwakhiweni. Lo mkhiqizo ungasetshenziswa futhi kuzimonyo ngendlela yesisombululo esigxilile esingu-50%. |
| i-glutamic acid | I-glutamic acid iyi-amino acid eyakha iphrotheni, inochungechunge oluseceleni lwe-ionized acidic, futhi ibonisa i-hydrotropism. I-Glutamic acid isengozini yokwenziwa i-cyclization ibe yi-pyrrolidone carboxylic acid, i.e., i-pyroglutamic acid. i-glutamic acid iphezulu kakhulu kuwo wonke amaprotheni okusanhlamvu, ihlinzeka nge-alpha-ketoglutarate ngomjikelezo we-tricarboxylic acid. I-Alpha ketoglutaric acid ingenziwa ngokuqondile kusuka ku-ammonia ngaphansi kwe-catalysis ye-glutamate dehydrogenase ne-NADPH (coenzyme II), futhi ingabuye ifakwe nge-aspartate aminotransferase noma i-alanine aminotransferase, i-glutamic acid ikhiqizwa ngokudluliselwa kwe-aspartic acid noma i-alanine; Ngaphezu kwalokho, i-glutamic acid ingashintshwa ngokushintshayo nge-proline ne-ornithine (kusuka ku-arginine), ngokulandelana. Ngakho-ke i-Glutamate iyi-amino acid engabalulekile ngokomsoco. Lapho i-glutamic acid ikhishwa ngaphansi kwe-catalysis ye-glutamate dehydrogenase ne-NAD (coenzyme I) noma idluliselwa ngaphandle kweqembu le-amino ngaphansi kwe-catalysis ye-aspartate aminotransferase noma i-alanine aminotransferase ukuze kukhiqizwe i-alpha ketoglutarate, ingena kumjikelezo we-tricarboxylic acid futhi ikhiqize ushukela ngokusebenzisa I-gluconeogenic pathway, ngakho-ke i-glutamic acid iyi-amino acid ebalulekile ye-glycogenic. i-glutamic acid ezicutshini ezihlukene (njengemisipha, isibindi, ubuchopho, njll.) ingahlanganisa i-glutamine ne-NH3 ngokusebenzisa i-glutamine synthetase, iwumkhiqizo wokukhipha ubuthi be-ammonia, ikakhulukazi ezicutshini zobuchopho, kanye nendlela yokugcina nokusebenzisa ammonia emzimbeni (bheka "glutamine and its metabolism"). i-glutamic acid ihlanganiswa ne-acetyl-CoA njenge-cofactor ye-mitochondrial carbamoyl phosphate synthase (ehilelekile ekuhlanganiseni kwe-urea) ngokusebenzisa i-catalysis ye-acetyl-glutamate synthase. I-γ-aminobutyric acid (GABA) ingumkhiqizo we-decarboxylation ye-glutamic acid, ikakhulukazi ekugxilweni okuphezulu kwezicubu zobuchopho, futhi ivela egazini, umsebenzi wayo wokuphila uthathwa njenge-neurotransmitter evimbelayo, imiphumela ye-antispasmodic kanye ne-hypnotic eyenziwa Ukufakwa komtholampilo kwe-echinocandin kungafinyelelwa nge-GABA. I-catabolism ye-GABA ingena kumjikelezo we-tricarboxylic acid ngokuguqula i-GABA transaminase ne-aldehyde dehydrogenase ibe yi-succinic acid ukuze yakhe i-GABA shunt. |
| Sebenzisa | isetshenziswa njengezimaphakathi ku-organic synthesis, izithasiselo zokudla, njll. esetshenziswa ekudleni, emithini, kwezimonyo nakwezinye izimboni |
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