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I-Levodopa (CAS# 59-92-7) Isithombe Esifakiwe
  • Levodopa (CAS# 59-92-7) 1

I-Levodopa (CAS# 59-92-7)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C9H11NO4
I-Molar Mass 197.19
Ukuminyana 1.3075 (isilinganiso esinzima)
I-Melting Point 276-278 °C (okhanyisiwe)
I-Boling Point 334.28°C (isilinganiso esinzima)
Ukuzungezisa Okuthile(α) -11.7 º (c=5.3, 1N HCl)
I-Flash Point 225°C
Ukuncibilika kwamanzi Incibilika kancane emanzini, nciphisa i-hydrochloric acid ne-formic acid. Ayincibiliki ku-ethanol.
Ukuncibilika Incibilika kalula ku-dilute hydrochloric acid ne-formic acid, inyibilika emanzini, ayincibiliki ku-ethanol, benzene, chloroform ne-ethyl acetate
I-Vapor Presure 7.97E-09mmHg ku-25°C
Ukubukeka Impushana ecwebezelayo emhlophe ukuya ku-milky
Umbala Okumhlophe kuya kokhilimu
I-Merck 14,5464
I-BRN 2215169
pKa 2.32(ku-25℃)
Isimo Sesitoreji 2-8°C
Ukuzinza Izinzile. Akuhambisani nama-oxidizing agents aqinile. Izwela ukukhanya nomoya.
Kuyazwela Izwela ukukhanya nomoya
I-Refractive Index -12 ° (C=5, 1mol/LH
I-MDL I-MFCD00002598
Izakhiwo Zomzimba Nezamakhemikhali iphoyinti lokuncibilika 295°C
ukuzungezisa okuthile kokubona -11.7 ° (c = 5.3, 1N HCl)
Sebenzisa Isidakamizwa esisebenzayo ekwelapheni ukukhubazeka kokushaqeka, ikakhulukazi esetshenziselwa i-Parkinson's syndrome, njll

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi I-Xn - Iyingozi
Amakhodi Engozi I-R22 – Iyingozi uma igwinywe
R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R20/21/22 – Kuyingozi ngokuhogela umoya, ukuthintana nesikhumba futhi uma ukugwinyile.
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S36 – Gqoka izingubo ezifanele zokuzivikela.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-WGK Germany 3
I-RTECS AY5600000
AMAKHODI E-FLUKA BRAND F 10-23
I-TSCA Yebo
Ikhodi ye-HS 29225090
Ubuthi I-LD50 kumagundane (mg/kg): 3650 ±327 ngomlomo, 1140 ±66 ip, 450 ±42 iv, >400 sc; kumagundane wesilisa, abesifazane (mg/kg): >3000, >3000 ngomlomo; 624, 663 ip; >1500, >1500 sc (Clark)

 

Isingeniso

Imiphumela ye-Pharmacological: izidakamizwa ezivimbela ukuthuthumela. Ingena esicutshini sobuchopho ngokusebenzisa umgoqo wegazi nobuchopho, futhi i-decarboxylated yi-dopa decarboxylase bese iguqulwa ibe i-dopamine, edlala indima. Isetshenziselwa ukukhubazeka okuyisisekelo kokuthuthumela kanye ne-non-drug-induced tremor paralysis syndrome. Kunomphumela omuhle kubantu asebekhulile abaphakathi nendawo, abanzima noma abampofu.

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