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I-Metadoxine (CAS# 74536-44-0) Isithombe Esifakiwe
  • I-Metadoxine (CAS# 74536-44-0) 1

I-Metadoxine (CAS# 74536-44-0)

Isakhiwo Samakhemikhali:

I-Molecular Formula C8H11NO3.C5H7NO3
I-Molar Mass 298.293
I-Melting Point 102-104°C
Ukuncibilika I-DMSO (Kancane), i-Methanol (Kancane)
Ukubukeka Okuqinile
Umbala Okumhlophe kuya Kokuphuzi Okukhanyayo
Isimo Sesitoreji Ivalwe endaweni eyomile, engu-2-8°C
Sebenzisa Ukunqunywa kokuqukethwe yi-HPLC
Isifundo se-in vitro Ukwelashwa ngesikhathi esisodwa kwe-Metadoxine kuvimbela ngokuphawulekayo ukuhlukaniswa kwe-adipogenic ngendlela encike kumthamo. Ukwelashwa kwe-metadoxine kusukela osukwini lwesi-4 kuye osukwini lwesi-8 kuyadingeka ukuze kuvinjwe ukuhlukaniswa kwe-preadipocyte eyenziwe yi-MDI. I-Metadoxine ivimbela ukuncipha kwe-glutathione kanye nokwanda komonakalo we-lipid peroxidation obangelwa i-ethanol ne-acetaldehyde kumaseli e-HepG2. Kumaseli e-hepatic stellate, i-Metadoxine ivimbela ukwanda kwe-collagen kanye nokukhishwa kwe-TNF-α encishisiwe okubangelwa i-acetaldehyde. Ngakho-ke, i-Metadoxine ingaba wusizo ekuvimbeleni umonakalo okhiqizwa ezigabeni zokuqala zesifo sesibindi sotshwala njengoba ivimbela ukungalingani kwe-redox kwe-hepatocytes futhi ivimbele ukungeniswa kwe-TNF-α, esinye sezehlakalo zakuqala emonakalweni wesibindi.

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Isingeniso

I-Metadoxin, ngamakhemikhali eyaziwa ngokuthi i-N,N-dimethylformamide, iwuketshezi olungenambala. Izici zayo zimi kanje:

 

Izakhiwo zomzimba: I-Metadoxine iwuketshezi olungenambala olunephunga elimnandi, oluguquguqukayo ezingeni lokushisa lasekamelweni, oluxubene namanzi kanye nezincibilikisi eziphilayo ezivame kakhulu.

 

Izakhiwo zamakhemikhali: I-Metadoxine iyinhlanganisela enciphisa kakhulu engenziwa i-hydrolyzed nge-sodium hydroxide noma i-sodium carbonate solutions ukuze yakhe i-formamide ne-methanol.

 

Ukusetshenziswa kwe-metaxacin:

 

I-Catalyst: I-Metadoxine ingasetshenziswa njengesithwali sezinsimbi zensimbi, futhi isetshenziselwa ukuvuselela ukusabela kwe-formylation yama-amine ku-organic synthesis.

 

Izinto ezincibilikisayo: I-Metadoxine isetshenziswa kakhulu njengesinyibilikisi ku-organic synthesis, njengokuncibilikisa izakhiwo zensimbi, ama-polymers, kanye nezimaphakathi zokusabela kwe-catalytic.

 

Indlela yokulungiselela: Ukulungiswa kwe-metadoxine ngokuvamile kutholakala ngokusabela kwe-formamidine ne-formic acid.

 

Ulwazi lokuphepha: I-Metaxacin iyacika futhi idlangile, futhi inomphumela ocasulayo esikhumbeni, emehlweni kanye nolwelwesi lwamafinyila. Kufanele kuqashelwe ukugwema ukuthintana ngqo nesikhumba namehlo, futhi amagilavu ​​okuzivikela kanye nezibuko kufanele kugqokwe uma kunesidingo. Kumele kuqashelwe ukuthi kungene umoya ngesikhathi sokusetshenziswa ukuze kugwenywe ukuhogela umhwamuko wawo. I-Meltadoxine iyinto evuthayo futhi kufanele igcinwe kude namalangabi avulekile kanye nemithombo yokushisa ephezulu.

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