I-Methoxymethyl triphenylphosphonium chloride (CAS# 4009-98-7)

Isebenzisa

(I-Methoxymethyl) i-triphenylphosphorus chloride isetshenziselwa ukuhlanganiswa kwe-cefaltacin, okuwumuthi ovimbela amagciwane kanye ne-anti-tumor. Ibuye isetshenziselwe ukwenza ucezu lwe-paclitaxel.

Ukulungiselela

Indlela yokuhlanganisa (i-methoxymethyl) i-triphenylphosphorus chloride, ehlanganisa lezi zinyathelo ezilandelayo: ngaphansi kokuvikelwa kwe-nitrogen, ingeza u-50mL we-acetone e-anhydrous ku-reactor, bese wengeza u-32g we-triphenylphosphine, ugqugquzela futhi ukhuphule izinga lokushisa ku-37 ° C, ukugcina izinga lokushisa eliqhubekayo. , yengeza u-20g we-methyl chloromethyl ether ku-reactor, bese isabela ku- I-37°C ye-3h, ikhuphula kancane izinga lokushisa libe ngu-47°C ngesilinganiso esingu-1°C/min, ukusabela kwaqhutshekwa nge-3h, ukusabela kwamiswa, kwathi i-37.0g (methoxymethyl) i-triphenylphosphorus chloride yatholwa ngokuhlunga, i-anhydric. ukugeza i-ether nokomisa ngesivuno esingu-88.5%.