I-Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Ubungozi Nokuphepha
| I-Hazard Class | 6.1 |
Indlela yokukhiqiza
inhlanganisela ehlosiwe yalungiswa nge-oxidation, i-amidation kanye nokuphelelwa amandla kwamanzi nge-methyl 2-methyl 4-pyridinecarboxylate (2) njengento yokuqala. ukwakheka kwayo kuqinisekiswe yi-1H NMR kanye ne-MS, futhi isamba sesivuno sasingu-53.0%. Imiphumela yesilinganiso sokuphakelayo, izinga lokushisa lekristalu, isikhathi sokusabela nezinye izici kumkhiqizo zacwaningwa ngokuhlolwa kwesici esisodwa, futhi izimo zenqubo zathuthukiswa: n(2):n (potassium permanganate) = 1.0:2.5, izinga lokushisa le-crystallization 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, ukusabela; ukusabela kokuphelelwa amanzi emzimbeni kukhetha uhlelo lwe-trifluoroacetic anhydride-triethylamine njenge-agent eqeda amanzi emzimbeni. Inqubo ilula ukuyisebenzisa, izimo zokusabela zithambile, kulula ukukhuphula ukukhiqizwa, futhi inenani elihle lesicelo esisebenzayo.
Sebenzisa
I-Tobisostat isetshenziselwa ukwelapha i-hyperuricemia engapheli ye-gout. Uma kuqhathaniswa nezidakamizwa zendabuko i-allopurinol (i-purine analog), ngeke ithinte i-purine ne-pyridine metabolism kanye nomsebenzi we-enzyme, futhi inciphisa i-uric acid Umphumela unamandla, akukho ukuphathwa okuphindaphindiwe komthamo omkhulu odingekayo, futhi ukuphepha kungcono. I-Methyl 2-cyano-4-pyridine carboxylate iyimpahla ebalulekile yokwenziwa kwe-Tobiso.
