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I-Mitotan (CAS# 53-19-0) Isithombe Esifakiwe
  • I-Mitotan (CAS# 53-19-0) 1

I-Mitotan (CAS# 53-19-0)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C14H10Cl4
I-Molar Mass 320.04
Ukuminyana 1.3118 (isilinganiso esinzima)
I-Melting Point 77-78°C(lit.)
I-Boling Point 405.59°C (isilinganiso esinzima)
Ukuncibilika kwamanzi <0.1 g/100 mL ku-24 ºC
Ukuncibilika I-DMSO: i-soluble20mg/mL, icacile
Ukubukeka impushana
Umbala okumhlophe kuya ku-beige
I-Merck 13,6237 / 13,6237
I-BRN 2056007
Isimo Sesitoreji Umkhathi ongenayo, izinga lokushisa legumbi
I-Refractive Index 1.6000 (isilinganiso)
Izakhiwo Zomzimba Nezamakhemikhali Iphuzu lokuncibilika lingu-76-78°C
ukuncibilika emanzini <0.1g/100 mL ku-24°C
Sebenzisa Lo mkhiqizo ngowocwaningo lwesayensi kuphela futhi ngeke usetshenziselwe ezinye izinjongo.
Isifundo se-in vitro Emgqeni weseli wegundane we-TalphaT1, i-Mitotane ivimbela inkulumo nokukhishwa kwe-TSH, ivimbela impendulo ye-TSH ku-TRH, futhi inciphisa ukusebenza kweseli, futhi ibangele i-apoptosis. Emangqamuzaneni egundane akhiqiza i-TSH-pituitary, i-Mitotane ayiphazamisi i-hormone ye-thyroid, kodwa inciphisa ngokuqondile umsebenzi we-secretory nokusebenza kweseli. I-Mitotane yenza i-adrenal cortical necrosis, ukulimala kwe-mitochondrial membrane, kanye nokubophezela okungenakuhlehliswa ku-CYP yamaprotheni. I-Mitotane(10-40 μm) ivimbele ukukhiqizwa kwe-cortisol ye-basal kanye ne-cAMP kodwa ayizange ibangele ukufa kweseli. I-Mitotane ibonise imiphumela yokuvimbela kumaprotheni e-basal Star kanye ne-P450scc. I-Mitotane(40 μm) inciphise kakhulu amazinga e-mRNA e-Star, CYP11A1 ne-cyp21. I-Mitotane(40 μm) icishe yaqeda ngokuphelele ukufakwa kwe-STAR, CYP11A1, CYP17, ne-CYP21 mRNA nge-adenosine 8-bromo-cyclic phosphate. Esigabeni se-S samaseli e-H295R, inhlanganisela ye-Mitotane ne-gemcitabine ibonise ukuphikisa futhi iphazamise ukuvinjelwa kwe-gemcitabine-mediated emjikelezweni weseli.
Isifundo se-vivo Emagundaneni, i-Mitotane (60 mg/kg) inciphise kakhulu i-adrenal mitochondrial ne-microsomal “P-450” kanye namaprotheni e-microsomal ngo-34%,55% no-35%.

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi I-Xn - Iyingozi
Amakhodi Engozi 40 - Ubufakazi obulinganiselwe bomphumela we-carcinogenic
Incazelo Yokuphepha 36/37 - Gqoka izingubo zokuzivikela ezifanele namagilavu.
Ama-ID e-UN 3249
I-WGK Germany 3
I-RTECS KH7880000
Ikhodi ye-HS 2903990002
I-Hazard Class 6.1(b)
Iqembu Lokupakisha III

 

Isingeniso

I-Mitotane iyinhlanganisela yezinto eziphilayo enegama lamakhemikhali elithi N,N'-methylene diphenylamine. Okulandelayo yisingeniso sezakhiwo, ukusetshenziswa, izindlela zokulungiselela kanye nolwazi lokuphepha lwe-mitotane:

 

Ikhwalithi:

- I-Mitotane iyikristalu eqinile engenambala encibilika kuzincibilikisi zemvelo ezifana ne-ethanol, i-ether, ne-chloroform.

- I-Mitotane inephunga elimnandi elinamandla.

 

Sebenzisa:

- I-Mitotane isetshenziselwa ikakhulukazi ukuhlanganisa ukusabela ku-organic synthesis futhi ivame ukusetshenziswa njenge-reagent kanye ne-catalyst.

- Ingabamba iqhaza ekuphenduleni kwamakhemikhali okuhlukahlukene, njengokuhlangana kwama-alkynes, i-alkylation yama-aromatic compounds, njll.

 

Indlela:

- I-Mitotane ingahlanganiswa ngokusabela okuyizinyathelo ezimbili. I-formaldehyde isabela ne-diphenylamine ngaphansi kwezimo ze-alkali ukuze yakhe i-N-formaldehyde diphenylamine. Khona-ke, nge-pyrolysis noma ukusabela kwe-oxidation okulawulwayo, iguqulwa ibe mitotane.

 

Ulwazi Lokuphepha:

- I-Mitotane iyinhlanganisela ecasulayo futhi akufanele ihlangane ngqo nesikhumba namehlo. Izimpahla zokuzivikela ezifanele njengamagilavu, izibuko, nezingubo zokuzivikela kufanele zigqokwe lapho kusebenza.

- Lapho ugcina futhi uphatha, qaphela ukuvala nokuvikela ekukhanyeni ukugwema ukuthintana nomoya kanye nomswakama.

- I-Mitotane ibola emazingeni okushisa aphezulu ukuze ikhiqize amagesi anobuthi, igweme ukushisa noma ukuthintana nezinye izinto ezivuthayo.

- Bheka imithetho yendawo bese ulandela izinqubo ezifanele zokusebenza zokuphepha lapho uzilahla.

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