I-N(alpha)-fmoc-N(epsilon)-(2-chloro-Z)-L-lysine(CAS# 133970-31-7)

I-Fmoc-(2-chlorobenzyloxycarbonyl) i-lysine iwukuphuma kwe-amino acid evame ukusetshenziswa enezici ezilandelayo:1. Ukubukeka: i-crystalline powder emhlophe;
2. ifomula yamangqamuzana: C26H24ClNO5;
3. Isisindo samangqamuzana: 459.92g/mol;
4. I-Solubility: I-Soluble ku-organic solvents njenge-dimethyl sulfoxide (DMSO), i-dimethyl formamide (DMF), i-dichloromethane, njll., engancibiliki emanzini;
5. Iphuzu lokuncibilika: cishe ku-170-175°C. Ukusetshenziswa okuyinhloko kwe-Fmoc-(2-chlorobenzyloxycarbonyl) lysine kuyiqembu elivikelayo nelisebenzayo ekuhlanganisweni kwama-polypeptides. Iqembu layo le-carboxyl lingenziwa lisebenze ukuze lenze i-ester, ebese ibhekana nokusabela kokujiya nensalela ye-amino acid ukuze kuhlanganiswe iketango le-polypeptide. Iqembu le-Fmoc lingasuswa kalula ngemva kokuba ukusabela sekuqediwe ukuze kudalule i-amino moiety evikelwe.

Indlela yokulungisa i-Fmoc-(2-chlorobenzyloxycarbonyl) lysine ngokuvamile ihlanganisa lezi zinyathelo ezilandelayo:

1. i-lysine esabelayo nge-N-hydroxybutyrimide (Pbf) ukwethula iqembu elivikelayo;
2. isabela kokuphuma kokunye kwe-lysine-Pbf ngotshwala obu-2-chlorobenzyl ukwenza i-Fmoc-(2-chlorobenzyloxycarbonyl) i-lysine;
3. Umkhiqizo ukhishwa nge-solvent efanele futhi uhlanjululwe nge-crystallization ukuze uthole umkhiqizo ohlanzekile.

Mayelana nolwazi lokuphepha, i-Fmoc-(2-chlorobenzyloxycarbonyl) lysine iyisisetshenziswa samakhemikhali futhi kufanele kuthathwe izinyathelo ezifanele zokuphepha. Izinto ezisetshenziswayo zokuvikela ezifanele, njengamagilavu ​​zelebhu, izibuko, nezingubo zaselabhu, kufanele zigqokwe ngesikhathi sokuhlolwa. Gwema ukuhogela izimpushana noma izixazululo, gwema ukuthintana nesikhumba namehlo. Uma kwenzeka ukuthintana ngephutha, hlambulula ngokushesha ngamanzi amaningi futhi ufune usizo lwezokwelapha. Qinisekisa ukuthi isetshenziswa endaweni ephephile yaselabhorethri futhi igcinwe ngendlela ukuvikela izingozi.