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I-N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine (CAS# 180570-71-2) Isithombe Esifakiwe
  • I-N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine (CAS# 180570-71-2) 1

I-N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine (CAS# 180570-71-2)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C38H32N2O5
I-Molar Mass 596.67
Ukuminyana 1.271±0.06 g/cm3(Kubikezelwe)
I-Melting Point 211-216°C
I-Boling Point 858.1±65.0 °C(Kubikezelwe)
Ukuncibilika I-Acetonitrile (Kancane), I-Chloroform (Kancane), I-Methanol (Kancane)
Ukubukeka Okuqinile
Umbala Okumhlophe kuya kokumhlophe
pKa 3.79±0.10(Okubikezelwe)
Isimo Sesitoreji 2-8°C
Ukuzinza I-Acid Iyazwela
I-Refractive Index 1.655
I-MDL I-MFCD00151919

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

I-WGK Germany 3
Ikhodi ye-HS 29242990
I-Hazard Class I-IRRITANT

I-N-(9-Fluorenylmethyloxycarbonyl)-N'-trityl-D-asparagine (CAS# 180570-71-2) Isingeniso

I-Fmoc-D-Asn(Trt)-OH ingxube yemvelo enezici ezilandelayo:1. Izakhiwo zamakhemikhali: I-Fmoc-D-Asn(Trt)-OH iqinile emhlophe, encibilika kwezinye izincibilikisi eziphilayo njenge-dimethyl sulfoxide (DMSO) ne-methanol.

2. Sebenzisa: I-Fmoc-D-Asn(Trt)-OH iyi-reagent ebalulekile esetshenziswa emkhakheni we-polymer synthesis kanye ne-biochemistry. Ivame ukusetshenziswa ekuvikeleni amasu eqembu ekuhlanganiseni kwesigaba esiqinile ukuvikela amaqembu amino kuma-amino acid noma izingcezu ze-peptide. Leli qembu elivikelayo lingasuswa nge-hydrofluoric acid ngaphansi kwezimo ze-ammonia-alkaline ngemva kokuhlanganiswa.

3. Indlela yokulungiselela: Indlela yokulungiselela i-Fmoc-D-Asn(Trt)-OH iyinkimbinkimbi kakhulu, ngokuvamile idinga ukusebenzisa ukusabela kwezinyathelo eziningi. Indlela yokwenziwa evamile iwukusabela i-trityl amine ne-N-protected D-asparagine, bese yenza ukusabela kokuvikela ngaphansi kwezimo ezifanele ukuze kutholwe umkhiqizo wokugcina.

4. Ulwazi lokuphepha: Nakuba i-Fmoc-D-Asn(Trt)-OH iphephile uma kuqhathaniswa ngaphansi kwezimo ezivamile zokuhlola, ingase ibangele ukucasuka emehlweni, isikhumba kanye nendlela yokuphefumula. Ukusetshenziswa kufanele kulandele izinqubo zaselabhorethri futhi kusebenzise izinyathelo zokuzivikela ezifanele njengamagilavu, izibuko nezingubo zokuzivikela. Ngesikhathi sokusebenzisa nokugcina, gwema umlilo nama-oxidizing, futhi ugcine endaweni eyomile, epholile.

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