I-N-Boc-N'-(2-chlorobenzyloxycarbonyl)-L-lysine(CAS# 54613-99-9)
| Izimpawu Eziyingozi | Xi - Irritant |
| Amakhodi Engozi | 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba. |
| Incazelo Yokuphepha | S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha. S36 – Gqoka izingubo ezifanele zokuzivikela. I-S24/25 - Gwema ukuthintana nesikhumba namehlo. |
| I-WGK Germany | 3 |
| Ikhodi ye-HS | 29242990 |
Isingeniso
I-N-tert-butoxycarbonyl-N'-(2-chlorobenzyloxycarbonyl)-L-lysine isakhi semvelo, esivame ukubizwa ngokuthi i-CBZ-L-lysine. Okulandelayo uhlobo, ukusetshenziswa, indlela yokulungiselela kanye nolwazi lokuphepha kwenhlanganisela:
Ikhwalithi:
I-CBZ-L-lysine iyikristale engenambala eqinile enephunga elingavamile. Inoncibilika kahle futhi iyancibilika kuzincibilikisi ezivamile ezifana ne-methanol, i-chloroform, ne-dimethyl sulfoxide.
Sebenzisa:
I-CBZ-L-lysine ivame ukusetshenziswa njengelinye lamaqembu avikelayo amino ku-organic synthesis ukuvikela amaqembu asebenzayo amino azwelayo emvelweni. Ekuhlanganisweni kwenhlanganisela ye-peptide, i-CBZ-L-lysine ingasetshenziswa ukuvikela iqembu le-amino le-lysine ukuze kuvikelwe noma kulawulwe ukusebenza kabusha kwayo ekuphenduleni okuthile.
Indlela:
Ukulungiswa kwe-CBZ-L-lysine kuvame ukuqhutshwa yizinyathelo ezilandelayo: I-L-lysine isabela nge-carbon dioxide ukuze ithole i-carbonate ehambisanayo; Khona-ke, i-carbonate isabela nge-tert-butoxycarbonyl magnesium chloride ukuze ithole i-acetyl-protected lysine; Ibe isisabela nge-2-chlorobenzyl iodine chloride kanye ne-alkali ukuthola i-CBZ-L-lysine.
Ulwazi Lokuphepha:
Ukusetshenziswa kwe-CBZ-L-lysine kufanele kuhambisane nezinyathelo zokuphepha ezilandelayo: kungase kucasule amehlo, isikhumba kanye nomgudu wokuphefumula, futhi ukuxhumana okuqondile kufanele kugwenywe ngesikhathi sokusebenza. Izimpahla zokuzivikela ezifanele njengezingilazi zokuvikela amakhemikhali namagilavu kufanele kugqokwe ngesikhathi sokusetshenziswa. Kufanele isetshenziswe endaweni enomoya omuhle ukuze kugwenywe ukuhogela umhwamuko ovela enkomponi. Uma kwenzeka ingozi, indawo ethintekile kufanele igezwe ngokushesha ngamanzi amaningi futhi kufanele kufunwe nosizo lwezokwelapha.
