I-N-Boc-N'-trityl-L-glutamine (CAS# 132388-69-3)

I-WGK Germany	3
Ikhodi ye-HS	29242990

I-N-Boc-N '-trityl-L-glutamine (N-Boc-N'-trityl-L-glutamine, efushanisiwe njenge-Boc-Gln(Trt)-OH) iyinhlanganisela yezinto eziphilayo. Inezici ezilandelayo:1. Ukubukeka: i-crystalline powder emhlophe.
2. ifomula yamangqamuzana: C39H35N3O6
3. Isisindo sengqamuzana: 641.71g/mol
4. Iphuzu elincibilikayo: 148-151°C
5. Ukunyibilika: Kuncibilika kuzincibilikisi eziningi eziphilayo, njenge-dimethyl sulfoxide (DMSO) ne-dichloromethane.
6. Ukuzinza: kuzinzile ngaphansi kwezimo zokuhlola ezivamile.

Ekuhlanganiseni kwamakhemikhali, i-N-Boc-N '-trityl-L-glutamine ivamise ukusetshenziswa njengeqembu elivikela ama-amino acid noma okumaphakathi. Ukusetshenziswa kwayo okuyinhloko kuhlanganisa:

1. esetshenziswa njengeqembu elivikela i-glutamine ku-peptide kanye ne-protein synthesis.
2. Ocwaningweni lwezidakamizwa zokwenziwa, isetshenziselwa ukuhlanganisa ama-analogues e-glutamine.
3. esetshenziswa njengesiphakathi ukuze kuhlanganiswe ezinye izinhlanganisela eziphilayo.

Indlela yokulungiselela i-N-Boc-N '-trityl-L-glutamine ngokuvamile imi kanje:

1. Okokuqala, phendula i-N-protected glutamine (efana ne-N-Boc-L-glutamine) ne-trityl halide (njenge-trityl chloride) ukuze uthole i-N-Boc-N '-trityl-L-glutamine.

Ulwazi Lokuphepha:
I-N-Boc-N '-trityl-L-glutamine, njengenhlanganisela yezinto eziphilayo, iphephile uma kuqhathaniswa ngaphansi kokusetshenziswa nokugcinwa okulungile. Nokho, lezi zindaba ezilandelayo zisadinga ukuqashelwa:

1. Gwema ukuthintana namehlo, isikhumba kanye nomgudu wokuphefumula. Sebenzisa amagilavu ​​okuvikela amakhemikhali kanye nezibuko.
2. Gcina endaweni eyomile, epholile.
3. Landela izinqubo zokuphepha futhi uphathe kahle futhi ulahle imfucuza yenhlanganisela.