I-N-Cbz-D-Tryptophan(CAS# 2279-15-4)

Isingeniso

I-N(^ a)-Benzyloxycarbonyl-D-tryptophan(N(^ a)-Benzyloxycarbonyl-D-tryptophan) ikhemikhali, eyaziwa nangokuthi i-CBZ-D-Trp. Okulandelayo yincazelo yemvelo yayo, ukusetshenziswa, ukwakhiwa kanye nolwazi lokuphepha:

Imvelo:

I-N(^ a)-I-Benzyloxycarbonyl-D-tryptophan iyi-crystalline eqinile emhlophe kuya kokuphuzi. Iqinile uma kuqhathaniswa nezinga lokushisa lasekamelweni futhi ingagcinwa isikhathi eside ngaphansi kwezimo ezingenamanzi. Ayincibiliki emanzini, kodwa iyancibilika kwezinye izinyibilikisi eziphilayo njenge-methanol ne-dimethyl sulfoxide.

Sebenzisa:

I-N(^ a) -I-Benzyloxycarbonyl-D-tryptophan ivame ukusetshenziswa njengamaqembu avikelayo ku-organic synthesis, ikakhulukazi ku-chemical peptide synthesis. Ukusetshenziswa kwayo okuyinhloko njengokuphuma kuma-amino acid okuhlanganiswa kwamamojula athile ku-polypeptide noma amaketanga amaprotheni. Ingadlala indima ebalulekile ekuhlanganisweni kwemithi emisha ngale ndlela.

Indlela:

Ukulungiswa kwe-N(^ a) -Benzyloxycarbonyl-D-tryptophan kuvame ukwenziwa ngokuhlangana kwamakhemikhali. Okokuqala, i-benzyl alcohol ne-carbon dioxide kusabela ukwenza i-benzyloxycarboxylic acid, bese kuthi i-amino acid tryptophan kanye ne-benzyloxycarboxylic acid ifakwe esterified ukuthola umkhiqizo we-CBZ-D-Trp. Ukusabela kudinga usizo lwama-catalyst athile nezinto ezincibilikisa.

Ulwazi Lokuphepha:

I-N(^ a)-I-Benzyloxycarbonyl-D-tryptophan inolwazi olulinganiselwe lokuphepha, kodwa ngokusekelwe olwazini olutholakalayo, ngokuvamile ibhekwa njengobuthi. Ukuchayeka isikhathi eside noma ukuchayeka ngokweqile kungase kube nemiphumela emibi yezempilo. Ngakho-ke, izinyathelo ezifanele zokuphepha kufanele zithathwe lapho kusetshenziswa, kugcinwa futhi kusingathwa lesi sithako, okuhlanganisa ukugqoka izinto zokuzivikela ezifanele kanye nokuphatha endaweni enomoya omuhle. Ngesikhathi esifanayo, kuyadingeka ukulandela izinqubo ezifanele zokusebenza zokuphepha nezindlela zokulahla.

Sicela uqaphele ukuthi lesi sihloko siwukubukezwa kuphela kwenhlanganisela okukhulunywa ngayo, futhi isicelo esithile kanye nokuhlolwa kwengozi kufanele kwenziwe endaweni ethile yaselabhorethri. Ngaphambi kokusebenzisa noma iyiphi into yamakhemikhali, sicela uqiniseke ukuthi ufunda imininingwane efanele futhi uthintane nochwepheshe kusenesikhathi.