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I-N-Cbz-L-Threonine(CAS# 19728-63-3) Isithombe Esifakiwe
  • N-Cbz-L-Threonine (CAS# 19728-63-3) 1

N-Cbz-L-Threonine (CAS# 19728-63-3)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C12H15NO5
I-Molar Mass 253.25
Ukuminyana 1.2499 (isilinganiso esinzima)
I-Melting Point 101-103°C(lit.)
I-Boling Point 396.45°C (isilinganiso esinzima)
Ukuzungezisa Okuthile(α) -4.7 º (c=4, i-acetic acid)
I-Flash Point 261.3°C
Ukuncibilika cishe obala ku-Methanol
I-Vapor Presure 3.7E-11mmHg ku-25°C
Ukubukeka Impushana yekristalu emhlophe ukuya kokuphuzi
Umbala Okumhlophe kuya Kucishe kube mhlophe
I-BRN 2335409
pKa 3.58±0.10(Okubikezelwe)
Isimo Sesitoreji Ivalwe endaweni eyomile, Gcina efrijini, ngaphansi kuka -20°C
I-Refractive Index -4.9 ° (C=2, AcOH)
I-MDL I-MFCD00065948
Sebenzisa Isetshenziselwa ama-reagents e-biochemical, i-peptide synthesis.

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

Izimpawu Eziyingozi I-Xn - Iyingozi
Amakhodi Engozi R20/21/22 – Kuyingozi ngokuhogela umoya, ukuthintana nesikhumba futhi uma ukugwinyile.
R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha S22 - Ungaphefumuli uthuli.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
S36 – Gqoka izingubo ezifanele zokuzivikela.
S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-WGK Germany 3
Ikhodi ye-HS 29242990

 

 

N-Cbz-L-Threonine(CAS# 19728-63-3) Ulwazi

ukulungiselela engeza u-50mL we-L-Thr(30mmol) nesixazululo esipholile se-Na2CO3 esigcwele ebhodleleni lokusabela elingu-250mL, bese ugoqa futhi uncibilike kubhavu eqhweni. Yehlisa i-20mL ye-Z-OSu(39.4mmol) isixazululo se-acetone ebhodleleni lokusabela; Khuthaza ukusabela ku-25 ℃, i-TLC-UV fluorescence kanye nendlela yombala ye-ninhydrin qapha inqubo yokusabela. Ngemva kokusabela, engeza i-H2O20mL, khipha nge-Et2O(30mL × 2) ku-pH>9, qoqa isigaba samanzi, lungisa i-pH ibe ngu-3~4 nge-1.5NHCl, khipha nge-EtOAc(30mL × 3), hlanganisa isigaba se-organic, geza ngesisombululo se-NaCl esigcwele (25mL × 2), somile nge-anhydrous Na2SO4, hlola ubumsulwa I-TLC-ultraviolet fluorescence kanye nendlela yokuthuthukisa umbala we-ninhydrin, futhi ihwamuke ngaphansi kwengcindezi encishisiwe, i-vacuum drying ukuze kutholwe uketshezi olunamafutha aphuzi i-N-benzyloxycarbonyl-L-threonine, olugcinwa ekushiseni okuphansi.
Sebenzisa I-CBZ-L-threonine iwuhlobo oluvikelwe lwe-N-Cbz lwe-L-threonine (T405500). I-L-threonine iyi-amino acid ebalulekile futhi ivame ukusetshenziswa njengesiphakeli kanye nesengezo sokudla. Uhlobo oluguquguqukayo lwe-Escherichia coli lukhiqize inani elikhulu le-L-threonine ngezinjongo zocwaningo nezinjongo zokudla okunomsoco. I-L-threonine itholakala ngokwemvelo ezinhlanzini nasezinkukhuni futhi ihlanganiswa namanye amaprotheni abalulekile omzimba, njenge-hemoglobin ne-insulin.
Isetshenziselwa ama-reagents e-biochemical kanye ne-peptide synthesis.

 

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