Umkhakha wemithi yokwelapha uyaqhubeka nokuguquguquka, nezinhlanganisela ezithile ezithola ukunakwa kwamandla azo okwelapha kanye nezakhiwo zamakhemikhali eziyingqayizivele. Enye yezinhlanganisela, i-3-(trifluoromethyl)phenylacetic acid (CAS351-35-9), idonse ukunaka e-United States naseSwitzerland. Lesi sihloko sihlola izitayela zamanje, amandla emakethe kanye namathemba esikhathi esizayo ale nhlanganisela kulezi zimakethe ezimbili ezibalulekile.
Uhlolojikelele lwemakethe
I-3-(i-Trifluoromethyl) i-phenylacetic acid iyisiphakathi esishintshashintshashintshashintshayo esisetshenziswa ekuhlanganiseni imithi ehlukahlukene, ikakhulukazi ekuthuthukisweni kwemithi elwa nokuvuvukala kanye ne-analgesic. Iqembu layo eliyingqayizivele le-trifluoromethyl lithuthukisa i-lipophilicity kanye nokuzinza kwe-metabolic kwenhlanganisela ewumphumela, kuyenze ibe inketho ekhangayo kubathuthukisi bezidakamizwa. Izwe laseMelika nelaseSwitzerland, aziwa ngezimboni eziqinile zemithi, aseqhulwini ekuthuthukiseni le nhlanganisela.
E-United States, imakethe yemithi ibonakala ngamazinga aphezulu okuqamba kanye nokutshalwa kwezimali kocwaningo. Ukuba khona kwezinkampani ezinkulu zokwenza imithi kanye nohlaka oluqinile lokulawula lwe-FDA kusiza ukuthuthukiswa nokudayiswa kwemithi emisha. Isidingo se-3-(trifluoromethyl)phenylacetic acid kulindeleke ukuthi sikhule njengoba izinkampani zifuna ukudala imithi esebenza ngempumelelo enemiphumela engemihle embalwa.
ISwitzerland, ngakolunye uhlangothi, yaziwa ngamakhono ayo asezingeni eliphezulu okukhiqiza imithi kanye namakhono ocwaningo. Izwe liyikhaya lezinkampani eziningi ezihamba phambili zemithi ezitshala imali eningi ocwaningweni nasekuthuthukisweni. Imakethe yaseSwitzerland inaka ngokukhethekile ukuthuthukiswa komuthi onembayo kanye nemithi yokwelapha eqondiwe, lapho izinhlanganisela ezifana ne-3-(trifluoromethyl)phenylacetic acid zingadlala indima ebalulekile.
Imvelo Elawulayo
I-United States neSwitzerland zombili zinezinhlaka eziqinile zokulawula embonini yezemithi. E-United States, i-FDA yengamela inqubo yokugunyazwa kwemithi emisha futhi iqinisekisa ukuthi ihlangabezana namazinga okuphepha nokusebenza kahle. Ngokufanayo, i-Switzerland igcina izindinganiso eziqinile zokugunyazwa kwezidakamizwa ngaphansi kwe-Swiss Agency for Therapeutic Goods (Swissmedic). Lezi ziphathimandla zokulawula zibalulekile ekubumbeni ukuguquguquka kwemakethe ye-3-(trifluoromethyl)phenylacetic acid njengoba zithonya ijubane locwaningo nentuthuko kanye nokwethulwa kwemikhiqizo emisha.
Izinselelo Zemakethe
Ngaphandle kwamathemba ayo athembisayo, imakethe ye-3-(trifluoromethyl)phenylacetic acid isabhekene nezinselelo ezithile. Isithiyo esibalulekile izindleko eziphezulu zocwaningo nentuthuko, ezingase zivimbele izinkampani ezincane ukuthi zingene emakethe. Ukwengeza, inkimbinkimbi yokuhlanganisa le nhlanganisela nokuqinisekisa ikhwalithi engaguquki kubangela izinselele kubakhiqizi.
Ukwengeza, ukugxila okukhulayo kwemboni yezemithi ezinkambisweni ezisimeme nezingavumelani nemvelo kungase kube nomthelela ezindleleni zokukhiqiza ze-3-(trifluoromethyl)phenylacetic acid. Izinkampani zingaphansi kwengcindezi yokwamukela ubuchwepheshe obuluhlaza, obungaholela ekushintsheni kochungechunge lokuhlinzeka ngempahla nezinqubo zokukhiqiza.
ithemba
Uma ubheka phambili, imakethe ye-3-(trifluoromethyl)phenylacetic acid kulindeleke ukuthi ikhule e-United States naseSwitzerland. Ukusabalala okwandayo kwezifo ezingamahlalakhona kanye nesidingo semishanguzo emisha kuqhuba isidingo sezinhlanganisela ezintsha zemithi. Njengoba ucwaningo luqhubeka nokudalula izicelo ezingaba khona zale nhlanganisela, singabona ukwanda ekusetshenzisweni kwayo ekuthuthukisweni kwezidakamizwa.
Ukwengeza, ukusebenzisana phakathi kwezikhungo zezemfundo nezinkampani ezenza imithi kulindeleke ukuthi kuthuthukise isimo socwaningo futhi kuholele ekusetshenzisweni kwenoveli nokwakhiwa. Ukugxila emithini yomuntu siqu kanye nemithi yokwelapha ehlosiwe izophinda idale amathuba amasha e-3-(trifluoromethyl)phenylacetic acid, okuyenza ibe ngumdlali oyinhloko ekuthuthukisweni kwezidakamizwa esikhathini esizayo.
Kafushane, imakethe yezemithi ye-3-(trifluoromethyl)phenylacetic acid e-United States naseSwitzerland isendleleni ekhuphukayo, iqhutshwa ukuqanjwa okusha, ukwesekwa okulawulwayo, kanye nesidingo esikhulayo sezixazululo ezisebenzayo zokwelapha. Njengoba imboni iqhubeka nokuvela, le nhlanganisela ingase idlale indima ebalulekile ekubumbeni ikusasa lezokwelapha.
Isikhathi sokuthumela: Oct-30-2024