Amathrendi asafufusa emakethe ye-3,5-di-tert-butyl-4-hydroxybenzaldehyde: Abaphakathi Kwezemithi e-United States naseYurophu.

Isidingo semboni yezemithi sabaphakathi kwekhwalithi ephezulu, okubalulekile ekuhlanganiseni izinhlanganisela ezihlukahlukene zokwelapha, sikhule kakhulu eminyakeni yamuva. Phakathi kwalokhu okuphakathi, i-3,5-di-tert-butyl-4-hydroxybenzaldehyde (CAS#1620-98-0) isibe ngumdlali obalulekile ezimakethe zase-US naseYurophu. Eyaziwa ngezindawo zayo zamakhemikhali eziyingqayizivele kanye nokuguquguquka, le nhlanganisela isetshenziswa kakhulu ekukhiqizeni imithi, amakhemikhali e-agrochemicals namakhemikhali akhethekile.

I-3,5-di-tert-butyl-4-hydroxybenzaldehyde yaziwa kakhulu ngendima yayo njengendawo emaphakathi yezemithi. Iwumsebenzi oyisisekelo wokuhlanganiswa kwezithako ezehlukene zemithi (ama-API), ikakhulukazi lezo ezisetshenziselwa ukwelapha izifo ezingamahlalakhona njengomdlavuza, isifo senhliziyo nemithambo yegazi, kanye nesifo se-metabolic. Ikhono lenhlanganisela lokuthuthukisa ukusebenza kahle nokuzinza kokwenziwa kwemithi kwenze kwaba isithako esifunwa kakhulu kubakhiqizi bezidakamizwa.

Imakethe yase-US 3,5-di-tert-butyl-4-hydroxybenzaldehyde ibilokhu ikhula ngamandla, iqhutshwa ukwanda kokutshalwa kwezimali emisebenzini yocwaningo nentuthuko (i-R&D) eyenziwa yizinkampani ezithaka imithi. Ukwenyuka kwezifo ezingamahlalakhona kanye nesidingo esilandelayo sezindlela zokwelapha ezintsha kuqhubekisele phambili isidingo sabaphakathi bekhwalithi ephezulu. Ngaphezu kwalokho, imboni yemithi evuthiwe kanye nendawo yokulawula evumayo e-United States ibe nomthelela ekwandeni kokuthandwa kwale khompiyutha.

E-Europe, isimo siyefana, namazwe afana neJalimane, i-France ne-UK ahola ukusetshenziswa kwe-3,5-di-tert-butyl-4-hydroxybenzaldehyde. Imakethe yezemithi yaseYurophu ibonakala ngamazinga nemithethonqubo yekhwalithi eqinile, eyenza abakhiqizi bafune imithombo ethembekile yabaphakathi kwezemithi. Ikhompiyutha ihambisana neziqondiso ze-European Medicines Agency (EMA), okuyenza ibe inketho ekhangayo ezinkampanini ezifuna ukuthuthukisa iphothifoliyo yemikhiqizo yazo.

Ukwengeza, ukugxila okukhulayo kokusimama kanye nezinqubo zamakhemikhali aluhlaza e-United States naseYurophu kuholele ekushintsheni ekutholeni amakhemikhali aphakathi nendawo. Abakhiqizi manje babeka phambili abahlinzeki ababambelela ezinkambisweni ezihambisana nemvelo, okwandisa nakakhulu isidingo se-3,5-di-tert-butyl-4-hydroxybenzaldehyde. Izinkampani ezingakhombisa ukuzibophezela ezindleleni zokukhiqiza ezisimeme zingase zithole inzuzo yokuncintisana emakethe.

Uchungechunge lokuhlinzekwa kwe-3,5-di-tert-butyl-4-hydroxybenzaldehyde nalo luyavela, futhi abakhiqizi bahlola amasu amasha okuthola usizo ukuze baqinisekise ukuhlinzekwa okuzinzile kwalokhu okumaphakathi okubalulekile. Ukusebenzisana phakathi kwabakhiqizi bamakhemikhali nezinkampani ezenza imithi kuya ngokuya kuvame njengoba zombili zifuna ukuthuthukisa izinqubo zokukhiqiza nokunciphisa izindleko. Lo mkhuba kulindeleke ukuthi uqhubeke njengoba isidingo sabaphakathi bekhwalithi ephezulu sihlala siqinile.

Sengiphetha, imakethe ye-3,5-di-tert-butyl-4-hydroxybenzaldehyde njengendawo ephakathi kwezemithi kulindeleke ukuthi ikhule kakhulu e-United States naseYurophu. Ukuguquguquka kwenhlanganisela, ukuthobela izindinganiso zokulawula kanye nokuhambisana nezinjongo zentuthuko esimeme kuyenza ibe yigugu embonini yezokwenziwa kwemithi. Njengoba isidingo semithi emisha silokhu sikhula, ukubaluleka kweziphakathi ezinokwethenjelwa nezisezingeni eliphezulu ezifana ne-3,5-di-tert-butyl-4-hydroxybenzaldehyde kuzokhula kuphela, kulolonge isimo sesikhathi esizayo sokwenziwa kwemithi kulezi zifunda.