Imakethe yezemithi yaseYurophu ibhekene nezinguquko eziphawulekayo, eziqhutshwa isidingo esikhulayo sezindlela zokwelapha ezintsha kanye nokuthuthukiswa okuqhubekayo kwezinqubo zokukhiqiza izidakamizwa. Omunye wabadlali ababalulekile kulo mkhakha yi-2-aminobenzonitrile, okuphakathi kwemithi okubalulekile okudonse ukunaka okukhulu ngenxa yendima yayo ekuhlanganiseni i-lapatinib, ukwelapha okuhlosiwe okusetshenziselwa ngokuyinhloko ukwelapha umdlavuza webele.
I-2-Aminobenzonitrile, isihlonzi samakhemikhali1885-29-6, iyinhlanganisela enamakha eyisihluthulelo sokwakha ekukhiqizweni kwezinhlobonhlobo zemithi. Izici zayo zamakhemikhali eziyingqayizivele zenza kube okuphakathi okubalulekile ekuhlanganiseni kwe-lapatinib, i-dual tyrosine kinase inhibitor eqondise i-epidermal growth factor receptor (EGFR) kanye ne- human epidermal growth factor receptor 2 (HER2). Le ndlela yokusebenza inenzuzo ikakhulukazi ezigulini ezinomdlavuza webele we-HER2-positive, ihlinzeka ngendlela yokwelapha ehlosiwe enciphisa ukulimala kwamaseli anempilo uma kuqhathaniswa nokwelashwa ngamakhemikhali okungokwesiko.
Eminyakeni yamuva nje, isidingo se-lapatinib sikhule ngokwanda kwezigameko zomdlavuza webele kanye nokwanda kokuqwashisa ngokubaluleka kwemithi yomuntu siqu. Ngenxa yalokho, imakethe yabaphakathi kwezemithi, okuhlanganisa i-2-aminobenzonitrile, ikhula ngokushesha. Izinkampani ezithaka imithi zaseYurophu zitshala imali eningi ocwaningweni nasekuthuthukisweni ukuze kuthuthukiswe ukusebenza kahle kokukhiqizwa kwe-lapatinib, okubuye kuqhubekisele phambili isidingo sabaphakathi bekhwalithi ephezulu.
Enye yezinto ezibalulekile ezithonya imakethe ye-European 2-aminobenzonitrile indawo yokulawula eqinile yesifunda. I-European Medicines Agency (EMA) ibeke imihlahlandlela eqinile yokukhiqizwa nokulawulwa kwekhwalithi yabaphakathi kwezemithi, iqinisekisa ukuthi kufinyelelwa amazinga aphezulu kuphela. Lolu hlaka lokulawula alugcini nje ngokuvikela ukuphepha kwesiguli kodwa futhi lukhuthaza ukuqanjwa kabusha ngaphakathi kwemboni njengoba izinkampani zilwela ukuhambisana nalawa mazinga kuyilapho zisakha izindlela zokwenziwa ezintsha nezithuthukisiwe.
Ngaphezu kwalokho, imakethe yaseYurophu ibonakala ngokuthambekela okukhulayo kokusimama kanye namakhemikhali aluhlaza. Abakhiqizi bemithi baya ngokuya befuna izinqubo ezivumela imvelo ukukhiqiza okuphakathi okufana ne-2-aminobenzonitrile. Lolu shintsho luqhutshwa ingcindezi yokulawula kanye nesidingo sabathengi sezinqubo ezizinzile. Izinkampani zihlola ezinye izindlela zokuhlanganisa ukuze kuncishiswe imfucuza kanye nokunciphisa umthelela wemvelo wemisebenzi yazo, ngokuvumelana nezinjongo ezibanzi ze-European Green Deal.
Ngaphezu kokusimama, imakethe yezemithi yaseYurophu nayo ibhekene negagasi lokuthuthuka kwezobuchwepheshe. Ukuhlanganiswa kobuhlakani bokwenziwa (AI) nokufunda komshini enqubweni yokuthuthukiswa kwezidakamizwa kuguqula indlela abaxhumanisi bemithi abakhiqizwa ngayo. Lobu buchwepheshe buvumela izinkampani ukuthi zithuthukise izindlela zazo zokwenziwa, zehlise izindleko zokukhiqiza, futhi zisheshise isikhathi sokumaketha izidakamizwa ezibalulekile njenge-lapatinib.
Njengoba imakethe yezemithi yaseYurophu iqhubeka nokuthuthuka, indima yabaphakathi njenge-2-aminobenzonitrile izohlala ibucayi. Ucwaningo oluqhubekayo lwezinhlelo zokusebenza ezintsha nezindlela zokwenziwa kungenzeka luqhubekisele phambili emisha ekukhiqizeni i-lapatinib nezinye izindlela zokwelapha ezihlosiwe. Lokhu kuzothuthukisa izindlela zokwelapha zeziguli futhi kube nomthelela ekukhuleni okuphelele embonini yezemithi yaseYurophu.
Kafushane, ukuphambana kokuthotshelwa komthetho, ukusimama, kanye nokuqamba okusha kwezobuchwepheshe kwakha ikusasa lemakethe yezemithi yaseYurophu. Njengoba isidingo se-lapatinib nabaphakathi kwayo, njenge-2-aminobenzonitrile, siqhubeka sikhuphuka, ababambiqhaza kuyo yonke imboni kumele bazivumelanise nalezi zindlela ukuze bahlale bencintisana futhi bahlangabezane nezidingo eziguqukayo zeziguli. Ikusasa labaphakathi kwezemithi liqhakazile, futhi i-2-aminobenzonitrile ihamba phambili kulo mkhakha wezwe oguquguqukayo.
Isikhathi sokuthumela: Dec-12-2024