Ucingo:+86 21 6460 6569
isibhengezo_sekhasi

umkhiqizo

I-Nicorandil(CAS# 65141-46-0) Isithombe Esifakiwe
  • I-Nicorandil (CAS# 65141-46-0) 1

I-Nicorandil (CAS# 65141-46-0)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C8H9N3O4
I-Molar Mass 211.17
Ukuminyana 1.4271 (isilinganiso esinzima)
I-Melting Point 92°C
I-Boling Point 350.85°C (isilinganiso esinzima)
I-Flash Point 230°C
Ukuncibilika I-DMSO: >10 mg/mL. Incibilika ku-methanol, i-ethanol, i-acetone noma i-glacial acetic acid, inyibilika kancane ku-chloroform noma emanzini, cishe ayincibiliki ku-ether noma ku-benzene.
I-Vapor Presure 1.58E-08mmHg ku-25°C
Ukubukeka Impushana ecwebezelayo emhlophe ukuya kokumhlophe
Umbala okumhlophe kuya kokumhlophe
I-Merck 14,6521
Isimo Sesitoreji 2-8°C
I-Refractive Index 1.7400 (isilinganiso)
I-MDL I-MFCD00186520
Izakhiwo Zomzimba Nezamakhemikhali Impushana emhlophe ecwebezelayo, engenaphunga noma enephunga kancane, iyababa. Incibilika ku-methanol, i-ethanol, i-acetone noma i-acetic acid, inyibilika kancane ku-chloroform noma emanzini, okumbalwa akuncibiliki ku-ether noma ku-benzene. Iphoyinti lokuncibilika 88.5-93.5 °c. Ubuthi obukhulu LD50 amagundane (mg/kg):1200-1300 ngomlomo, 800-1000 emthanjeni.
Sebenzisa Ukuze uvimbele isifo senhliziyo, i-angina pectoris
Isifundo se-in vitro I-Nicorandil (100 mM) ikhuphule i-flavoprotein oxidation, kodwa ayizange ithinte i-membrane yamanje, ibuyisela iziteshi ze-mitoK(ATP) kanye ne-surfaceK(ATP) ekugxilweni okuphezulu kunokuphinda okungu-10. I-Nicorandil yehlisa ukufa kweseli kumodeli ye-ischemic granulation, umphumela we-cardioprotective ovinjwe isivimbeli sesiteshi se-mitoK(ATP) esingu-5-hydroxydecanoic kodwa hhayi nge-surfaceK(ATP). Umthelela wesivimbeli sesiteshi i-HMR1098. I-Nicorandil (100 mM) ivimbela ukulahleka kwe-TUNEL positivity, ukudluliselwa kwe-cytochrome C, ukwenziwa kusebenze kwe-caspase-3, namandla olwelwesi lwe-mitochondrial (i-Delta(Psi)(m)). Ukuhlaziywa kwamaseli angcoliswe i-fluorescence Delta(Psi)(m) -indicator, i-tetramethylrhodamine ethyl ester (TMRE) nge-fluorescence activated cell sorter ibonise ukuthi, i-nicorandil ivimbela ukuchithwa kwe-Delta(Psi)(m) ngendlela encike ekugxiliseni ingqondo (EC(50) ) cishe 40 mM, saturation 100 mM). Kuwo womabili amaseli aguquliwe, i-Nicorandil yenza kusebenze isiteshi esingu-80 pS K sokulungiswa okubuthakathaka ngaphakathi, esizwela i-glibenclamide-sensitive 80 pS. Kumaseli e-HEK293T, i-Nicorandil ngokuncamelayo yenza kusebenze isiteshi se-K(ATP) esiqukethe i-SUR2B. I-Nicorandil (100 mM) ivimbele ngokuphawulekayo inani lamaseli ku-TUNEL-positive nuclei futhi yandisa umsebenzi we-caspase-3 owenziwe ngu-20 mM h2o2. I-Nicorandil incike ekuvimbeleni ukulahlekelwa kwe-DeltaPsim okubangelwa yi-H2O2.
Isifundo se-vivo I-Nicorandil (2.5 mg/kg nsuku zonke, po) ihlanganiswe ne-Amlodipine (5.0 mg/kg nsuku zonke, po) izinsuku ezintathu zesenzo zavimbela kakhulu izinguquko futhi yabuyisela umsebenzi we-enzyme emazingeni aseduze nalawo amagundane avamile.

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Izimpawu Eziyingozi I-Xn - Iyingozi
Amakhodi Engozi I-R22 – Iyingozi uma igwinywe
R41 – Ingozi yokulimala okubi emehlweni
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S39 – Gqoka ukuvikela iso / ubuso.
I-WGK Germany 3
I-RTECS US4667600
Ikhodi ye-HS 29333990
Ubuthi I-LD50 kumagundane (mg/kg): 1200-1300 ngomlomo; 800-1000 iv (Nagano)

 

Isingeniso

I-Nicolandil, eyaziwa nangokuthi i-nicorandil amine, iyinhlanganisela yezinto eziphilayo. Okulandelayo yisingeniso sezakhiwo, ukusetshenziswa, ukulungiswa kanye nolwazi lokuphepha kwe-nicorandil:

 

Ikhwalithi:

- I-Nicorandil iyikristale eqinile engenambala encibilika emanzini nasezincibilikisini eziphilayo.

- Kuyinhlanganisela ye-alkaline ekwazi ukusabela nge-acids ukukhiqiza izinhlanganisela zikasawoti.

- I-Nicorandil izinzile emoyeni, kodwa ingase ibole lapho ibhekene namazinga okushisa aphezulu.

 

Sebenzisa:

- I-Nicolandil ingasetshenziswa futhi ekuhlanganiseni ama-organic synthesis catalysts, ama-photosensitizers, njll.

 

Indlela:

- I-Nicolandil ivame ukulungiswa ngokusabela kwe-dimethylamine kanye ne-2-carbonyl compounds.

- Ukusabela kwenziwa ngaphansi kwezimo ze-alkali futhi ukusabela kokushisa kwenziwa ku-solvent efanelekile.

 

Ulwazi Lokuphepha:

- I-Nicorandil iphephile uma kuqhathaniswa nabantu ngaphansi kwezimo ezijwayelekile.

- Nokho, kufanele kuqashelwe ukugwema ukuthintana ngqo namehlo, isikhumba, nesimiso sokuphefumula.

- Gqoka izinto zokuzivikela ezifanele (i-PPE) njengezingilazi zokuphepha, amagilavu ​​nezinto zokuphefumula.

- Uma usebenzisa noma ugcina i-nicorandil, ukunakekelwa kufanele kuthathwe ukuze kugwenywe ukushisa kanye nezimo zokushisa eziphezulu.

 

  • Okwedlule:
  • Olandelayo:
    • Bhala umyalezo wakho lapha futhi usithumelele wona

    imikhiqizo ehlobene