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(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3) Isithombe Esifakiwe
  • (S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3) 1

(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3)

Isakhiwo Samakhemikhali:

I-Molecular Formula I-C3H12Cl2N2
I-Molar Mass 147.05
I-Melting Point 238-243°C
I-Boling Point 215.8°C ku-760 mmHg
Ukuzungezisa Okuthile(α) -4 º (c=20 ku-H2O)
I-Flash Point 84.3°C
Ukuncibilika kwamanzi Incibilika emanzini
I-Vapor Presure 0.12mmHg ku-25°C
Ukubukeka powder kuya kukristalu
Umbala Okumhlophe kuya Kucishe kube mhlophe
I-BRN 5740936
Isimo Sesitoreji Umkhathi ongenayo, izinga lokushisa legumbi

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Ubungozi Nokuphepha

Amakhodi Engozi R36/37/38 – Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R23/24/25 – Kunobuthi ngokuhogela, ukuthintana nesikhumba futhi uma ugwinywe.
Incazelo Yokuphepha S26 – Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S36 – Gqoka izingubo ezifanele zokuzivikela.
S45 – Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu ​​kanye nokuvikela iso/ubuso.
I-WGK Germany 3
AMAKHODI E-FLUKA BRAND F 10-21
Ikhodi ye-HS 29212900

 

 

 

(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3) Ulwazi

Uhlolojikelele (S)-(-) -diaminopropane dihydrochloride ingasetshenziswa njenge-pharmaceutical synthesis intermediate, njengokulungiswa kwe-Dexrazoxane, iyi-enantiomer ye-dextrorotatory ye-antitumor drug razoxane. Ngezidakamizwa ezivikela inhliziyo, i-clinical for the Prevention of anthracycline anticancer drugs ebangelwa ubuthi benhliziyo kanye ne-leukemia ezinganeni ngenxa yokwelashwa ngamakhemikhali okubangelwa ukulimala kwenhliziyo, ngokuvamile njenge-adjuvant ekwelapheni umdlavuza.
Sebenzisa (S)-(-)-diaminopropane I-Dihydrochloride i-organic intermediate, ingalungiswa ngokusabela i-D-(-)-tartaric acid ne-propylenediamine.
I-diamine isetshenziswe ekuhlanganiseni ama-chiral imidazoline compounds
ukulungiselela ukulungiswa kwe-(S)-(-)-diaminopropane dihydrochloride: engeza u-30.0gD-(-)-tartaric acid kanye no-8.0 ml wamanzi kanye ne-g(±) -1, 2-propanediamine eflaskini yokusabela, gudluza ukuze uncibilike, pholisa, engeza I-Dropwise, izinga lokushisa liphakanyiswe ukuze libuyele emuva amahora angu-2 ngokugqugquzela. Ukunyakazisa kwamiswa, futhi izinga lokushisa lakhushulelwa ku-80 ° C. Ihora elingu-1. Khona-ke, izinga lokushisa lehliswa kancane kancane futhi kancane kancane libe izinga lokushisa elilingana negumbi, ukumuncwa kuhlungwe, futhi i-vacuum yomiswa ukuze kutholwe u-16.1g we-(S) -1, 2-propanediamine ditartrate. Engeza u-16.1g we-(S)-1, 2-propanediamine ditartrate kanye namanzi kufulaski wokusabela, chaza ngokufudumeza, bese wengeza isixazululo esingu-7.43g we-potassium chloride no-20ml wamanzi, ingxube yanyakaziswa ku-70 °c. amahora ama-2. Ngemva kokupholisa, isiqandisi sasivunyelwa ukuba sime ukuze sibe crystallization. I-filtrate yahlungwa ngokumuncwa futhi yacwiliswa ukuze yome ngaphansi kwengcindezi encishisiwe ukunikeza u-84% G wokuqinile okuphuzi (3), isivuno esingu-4.02,[α]20D =-°(C = 1%,H2O).
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