I-sodium nitroprusside dihydrate (CAS# 13755-38-9)

Isakhiwo Samakhemikhali:

I-Molecular Formula	I-C5H4FeN6Na2O3
I-Molar Mass	297.95
Ukuminyana	1.72
Ukuncibilika kwamanzi	Incibilika emanzini. I-ethanol encibilika kancane.
Ukuncibilika	Incibilika emanzini (400 g/l) ku-20 °C, ne-ethanol (incibilika kancane).
Ukubukeka	Ikristalu ebomvu ejulile
I-Gravity ethize	1.72
Umbala	I-Ruby ebomvu
Umkhawulo Wokuchayeka	I-ACGIH: TWA 1 mg/m3NIOSH: IDLH 25 mg/m3; TWA 1 mg/m3
I-Merck	14,8649
PH	5 (50g/l, H2O, 20℃)
Isimo Sesitoreji	2-8°C
Kuyazwela	I-Hygroscopic
I-MDL	I-MFCD00149192
Izakhiwo Zomzimba Nezamakhemikhali	Impushana yekristalu ensundu ngokubomvu, engenaphunga; Enganambitheki.
Sebenzisa	Isetshenziswa njenge-reagent ekunqumeni ama-aldehydes, i-acetone, isulfure dioxide, i-zinc, izinsimbi ze-alkali, ama-sulfide, njll.
Isifundo se-in vitro	I-Sodium Nitroprusside iyi-vasodilator esebenzayo. I-sodium nitroprusside inomphumela osebenzayo we-vasodilatory kuma-arterioles nama-venules. I-Sodium Nitroprusside idilika ekujikelezeni ukuze ikhulule i-nitric oxide (NO). I-NO yenza i-guanylate cyclase isebenze emisipha ebushelelezi ye-vascular futhi ikhulise ukukhiqizwa kwe-intracellular cGMP. Lokhu ekugcineni kuholela ekuphumuleni kwemisipha ebushelelezi ye-vascular, evula imithambo yegazi. I-nitroprusside ye-sodium inciphisa ukwanda kwemisipha ebushelelezi ye-vascular.
Isifundo se-vivo	I-nitroprusside ye-sodium (5 mg/kg) njengomnikezeli we-nitric oxide yanciphisa kakhulu ukulimala kwamathumbu e-ischemia-reperfusion kumagundane.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ubungozi Nokuphepha

Amakhodi Engozi	R25 – Kunobuthi uma ugwinywe R26/27/28 – Kunobuthi kakhulu ngokuhogela, ukuthintana nesikhumba futhi uma ugwinywe.
Incazelo Yokuphepha	S45 – Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.) S36/37/39 – Gqoka izingubo zokuzivikela ezifanele, amagilavu kanye nokuvikela iso/ubuso. S22 - Ungaphefumuli uthuli.
Ama-ID e-UN	UN 3288 6.1/PG 3
I-WGK Germany	3
I-RTECS	LJ8925000
AMAKHODI E-FLUKA BRAND F	3
I-TSCA	Yebo
Ikhodi ye-HS	28372000
I-Hazard Class	6.1
Iqembu Lokupakisha	III
Ubuthi	I-LD50 ngomlomo kuNogwaja: 99 mg/kg

13755-38-9 - Inkomba

Ireferensi

Bonisa okwengeziwe

1. Tian, Ya-qin, et al. "Ukuqhathaniswa kwamasu ahlukene okukhipha kanye nokwenza kahle kwe-extrac esizwa yi-microwave ...

13755-38-9 - Isingeniso

Incibilika emanzini, inyibilika kancane otshwaleni. Isixazululo saso esinamanzi asizinzile futhi singabola kancane kancane futhi sibe luhlaza.

13755-38-9 - Ulwazi Lwereferensi

isingeniso	i-sodium nitroprusside (ifomula yamangqamuzana: Na2[Fe(CN)5NO]· 2H2O, igama lekhemikhali: i-sodium nitroferricyanide dihydrate) iyi-vasodilator esheshayo futhi esebenza isikhathi esifushane, esetshenziswa ngokomtholampilo ekwelashweni okuphuthumayo okuphuthumayo njenge-hypertension, i-hypertension encephalopathy, I-hypertension eyingozi, i-paroxysmal hypertension ngaphambi nangemva kokuhlinzwa kwe-pheochromocytoma, njll, ingasetshenziswa futhi i-hypotension ngesikhathi sokuhlinzwa.
umphumela	I-sodium nitroprusside iyi-vasodilator enamandla esebenza ngokushesha, enomthelela oqondile wokwelula kumisipha ebushelelezi ye-arterial kanye ne-venous, futhi yehlisa ukumelana nemithambo yegazi ngokunwebisa imithambo yegazi., Khiqiza umphumela we-antihypertensive. Ukwehliswa kwemithambo kunganciphisa nomthwalo ngaphambi nangemva kwenhliziyo, kuthuthukise ukukhishwa kwenhliziyo, futhi kunciphise i-reflux yegazi lapho i-valve ivaliwe, ukuze kukhululeke izimpawu zokuhluleka kwenhliziyo.
izinkomba	1. isetshenziselwa i-hypotension ephuthumayo yezimo eziphuthumayo ze-hypertension, njenge-hypertension crisis, i-hypertensive encephalopathy, i-hypertension eyingozi, i-paroxysmal hypertension ngaphambi nangemva kokuhlinzwa kwe-pheochromocytoma, futhi ingasetshenziselwa ukulawulwa kwe-hypotension ngesikhathi sokuhlinzwa. 2. Ngokwehluleka kwenhliziyo okubuhlungu, okuhlanganisa i-acute pulmonary edema. Ibuye isetshenziselwe ukwehluleka kwenhliziyo okunamandla ku-acute myocardial infarction noma lapho i-valve (i-mitral noma i-aortic valve) ivaliwe.
i-pharmacokinetics	finyelela inani eliphakeme kakhulu legazi ngokushesha ngemuva kokudonswa komthambo, futhi izinga lalo lincike kumthamo. Lo mkhiqizo ugaywa amangqamuzana egazi abomvu abe yi-cyanide, i-cyanide esibindini iguqulwa ibe yi-thiocyanate, futhi i-metabolite ayinawo umsebenzi we-vasodilating; I-cyanide nayo ingabamba iqhaza ekusetshenzisweni kwe-vitamin B12. Lo mkhiqizo usebenza cishe ngokushesha ngemva kokuphathwa futhi ufinyelela inani eliphakeme kakhulu lesenzo, futhi ugcina imizuzu engu-1 ~ 10 ngemva kokuma kokuthonta emthanjeni. Uhhafu wempilo yeziguli ezinomsebenzi ojwayelekile wezinso yizinsuku eziyi-7 (kukalwa i-thiocyanate), isikhathi eside lapho ukusebenza kwezinso kungalungile noma i-sodium yegazi iphansi kakhulu, futhi ikhishwa yizinso.
Inqubo yokwenziwa yokulungiselela	i-sodium nitroprusside, okuhlanganisa nezinyathelo ezilandelayo: 1) Ukuhlanganiswa kwe-nitroso ferrocyanide yethusi: ukwengeza inani elifanele lamanzi ahlanzekile ukuze kuncibilike i-potassium nitroso-ferricyanide ethangini le-crystallization, ukushisa kufike ku-70-80 ℃ ukuze kuyincibilikise ngokuphelele, futhi kancane kancane wengeze i-copper sulfate pentahydrate. isisombululo se-aqueous dropwise, ngemuva kokuthi ukusabela kugcinwa kufudumele imizuzu engama-30, i-centrifuge, ikhekhe lesihlungi eli-centrifuged (i-copper nitroso ferricyanide) lafakwa ethangini le-crystallization. 2) I-synthetic sodium nitroprusside (i-sodium nitronitroferricyanide): Lungiselela isixazululo samanzi se-sodium bicarbonate esigcwele ngokwesilinganiso sokuphakelayo, bese uphonsa kancane kancane ku-nitroso ferricyanide ku-30-60 degrees C. Ngemva kokusabela, i-centrifuge, qoqa i-filtrate ne-lotion. 3) I-Concentration and crystallization: I-filtrate eqoqiwe kanye ne-lotion impontshelwa ethangini lokugxilisa le-vacuum, futhi i-acetic acid ecwebezelayo yengezwa kancane kancane kuze kube kungabikho amabhamuza akhiqizwayo. Vula iphampu ye-vacuum bese ushisa kufika ku-40-60 degrees C, qala ukugxila, ugxilise inani elikhulu lamakristalu emvula, vala i-valve yesitimu, i-vacuum valve ukuze ulungiselele i-crystallization. I-4) Ukomiswa kwe-Centrifugal: ngemva kwe-crystallization, i-supernatant isusiwe, amakristalu axutshwe ngokulinganayo futhi afakwe i-centrifuged, ikhekhe lokuhlunga lifakwa epuleti yensimbi engenasici, futhi umkhiqizo utholakala ngokumiswa kwe-vacuum.
umsebenzi webhayoloji	I-Sodium Nitroprusside iyi-vasodilator enamandla esebenza ngokukhulula ngokuzenzekelayo i-NO egazini.
Ithagethi	Inani
Sebenzisa	Isetshenziswa njenge-reagent ekunqumeni ama-aldehydes, ama-ketone, ama-sulfide, i-zinc, i-sulfur dioxide, njll. Isetshenziswa njenge-reagent ekunqumeni ama-aldehydes, i-acetone, isulfure dioxide, i-zinc, izinsimbi ze-Alkali, ama-sulfide, njll. Ama-Vasodilators. Ukuqinisekiswa kwe-aldehydes nama-ketones, i-zinc, i-sulphur dioxide kanye ne-alkali metal sulfide. Ukuhlaziywa kweChromatic, ukuhlolwa komchamo.