i-tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS# 845267-78-9)

I-Molecular Formula	I-C10H15NO4
I-Molar Mass	213.23
Ukuminyana	1.199
I-Boling Point	373.8±35.0 °C(Kubikezelwe)
I-Flash Point	179.9°C
I-Vapor Presure	8.72E-06mmHg ku-25°C
pKa	10.67±0.20(Okubikezelwe)
Isimo Sesitoreji	Gcina endaweni emnyama, evalwe endaweni eyomile, Emazingeni Okushisa Egumbi
I-Refractive Index	1.493
I-MDL	I-MFCD10566071

Imininingwane Yomkhiqizo

Amakhodi Engozi	20/21/22 – Kuyingozi ngokuhogela umoya, ukuthintana nesikhumba futhi uma kugwinywe.
Incazelo Yokuphepha	S23 – Ungawuphefumuli umhwamuko. I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-WGK Germany	3
Ikhodi ye-HS	29337900

Sebenzisa	I-2, i-4-dipiperidon-1-formate tert-butyl formate iwukuhlanganiswa kokuphuma kwe-phenoxymethyl-dihydrothiazolopyridone Ama-reactants emkhiqizweni, njengemoduli yesakhiwo esihle esikhethiwe (PAM) ye-glutamate 5(mGlu5) ye-metabolized receptor.
isicelo	I-2, 4-dioperidone-1-tert-butyl formate isetshenziswa ngokuyinhloko njenge-organic medium and pharmaceutical intermediate, futhi ingasetshenziswa ocwaningweni lwaselabhorethri nenqubo yokuthuthukiswa kanye nenqubo yokuhlanganisa imithi yamakhemikhali.
ukulungiselela	isinyathelo a: engeza i-EDCI(191.7g) ku-DMF(400mL) isixazululo se-3-(tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), i-meldamic acid (144.1g,1.0mol) ne-DMAP(135.0g,1.1mol) ) epholile ngokugeza eqhweni, 1.0mol). Ama-reactants angumphumela anyakaziswa ubusuku bonke endaweni yezinga lokushisa. Ukusabela kwacinywa ngo-200mL I-H2O. Ingxube ewumphumela yengezwe nge-dropwise ku-H2O(2.0L) ngaphansi kokunyakaziswa komshini. Okuqinile okutholakele kwahlungwa futhi kwagezwa kahle ngamanzi kuya ku-pH 7 ukuze kutholwe umkhiqizo (isivuno esingu-283g, 90%). Isinyathelo B: Isixazululo se-3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl)-3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) ku-toluene (1500mL) ishisiswe ku-100 ° C amahora angu-4. Izinto ezisabelayo zipholiswa ezingeni lokushisa elilingana negumbi futhi zigxiliswe ngaphansi kwengcindezi encishisiwe ukuze kutholwe umkhiqizo ongahluziwe. Umkhiqizo (isivuno esingu-56g, 83%) uhlanzwe ngokugaya kwe-MTBE.