I-Tetrahydropapaverine hydrochloride(CAS#6429-04-5)

I-Tetrahydropapaverine hydrochloride (CAS # 6429-04-5) iyinhlanganisela ebamba ukubaluleka okubalulekile emikhakheni efana nemithi.
Ngokubukeka, ngokuvamile ibonakala njengempushana emhlophe ecwebezelayo enozinzo oluhle lwesimo esiqinile, okwenza kube lula ukuyigcina nokuyihambisa. Ngokuphathelene ne-solubility, inezinga elithile lokuncibilika emanzini, elivumela ukuthi lihlakazwe kangcono emithonjeni yamanzi lapho kwenziwa amalungiselelo ahlobene. Ngasikhathi sinye, ingaphinda iveze izici ezithile zokuncibilika kwezinye izinyibilikisi eziphilayo, njenge-methanol, i-ethanol nezinye izinyibilikisi ze-alcohol organic.
Ngokombono wesakhiwo samakhemikhali, isakhiwo sayo samangqamuzana sine-nitrogen-containing heterocyclic moiety ekhethekile, esinikeza isisekelo esiyingqayizivele esihlobene nomsebenzi we-pharmacological. Ingakwazi ukusebenzisana nokunye okuhlosiwe kwebhayoloji emzimbeni, njengama-receptors athile, ama-enzyme, njll., futhi ibe nemiphumela ehambisanayo yokulawula ukuphathekayo komzimba. Ngaphezu kwalokho, ukuba khona kwe-hydrochloric acid akukhulisi nje kuphela ukuncibilika kwayo yonke inhlanganisela emanzini, kodwa futhi kuthinta ukuqina kwayo kwamakhemikhali kanye nezakhiwo ezihlobene ezifana ne-metabolism yezidakamizwa ngezinga elithile.
Emkhakheni wesicelo, isetshenziswa kakhulu embonini yezemithi njengesithako esisebenzayo semithi, esivame ukusetshenziselwa ukunciphisa izifo ezihlobene ezifana ne-vascular spasm. Ngokuphumula imisipha ebushelelezi ye-vascular kanye nokwenza ngcono ukujikeleza kwegazi lendawo, kunomphumela omuhle ekwelapheni i-adjuvant yezinye izifo zenhliziyo ne-cerebrovascular, futhi kungasiza ekudambiseni izimpawu zokungakhululeki ezibangelwa i-vascular spasm futhi kuthuthukise izinga lempilo yeziguli.
Ngesikhathi sokugcinwa nokusetshenziswa, kubalulekile ukuyibeka endaweni evaliwe futhi eyomile ukuze ugweme umswakama, njengoba umswakama ungase uthinte ukuzinza kwawo kwamakhemikhali kanye nesimo se-crystalline. Ngesikhathi esifanayo, kufanele igcinwe ngaphansi kwezimo zokushisa ezinqunyiwe, kude nezindawo zokushisa eziphakeme, ukuvimbela ukubola kanye ne-denaturation, futhi ilandele ngokuqinile imithethonqubo efanele yokugcina izidakamizwa nokusetshenziswa ukuze kuqinisekiswe ukuphepha nokusebenza kwemithi.